Results 91 to 100 of about 2,844 (161)

Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Tumour metabolic reprogramming initiates a vicious cycle of immunosuppression and therapy resistance. This synergy disarms immunity and fortifies tumour cells, ultimately driving clonal evolution of resistant disease. Abstract Background Glucose metabolic reprogramming is a hallmark of cancer, best exemplified by the Warburg effect.
Li Ma, Ming‐yang Wu, Cui‐cui Tian, Hao‐ze Shi, Dan Song   +4 more
wiley   +1 more source

Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]

, 2019
Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Chan, David C., Graham, Robert L. J., Hess, Sonja, Ladinsky, Mark S., Rojansky, Rebecca, Sweredoski, Michael J., Varuzhanyan, Grigor   +6 more
core  

Lactate‐mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension

The Journal of Pathology, Volume 267, Issue 4, Page 399-409, December 2025.
Abstract Chronic myeloid leukemia (CML) is a stem cell‐driven neoplasia characterized by the expression of the constitutively active tyrosine kinase (TK) BCR/Abl. Under low oxygen, a condition that characterizes stem cell niches (SCNs) in vivo, the oncogenic BCR/Ablprotein is suppressed.
Giulio Menegazzi, Dayana Desideri, Alessio Biagioni, Elisabetta Rovida, Persio Dello Sbarba, Silvia Peppicelli   +5 more
wiley   +1 more source

Association of Mitochondrial Pyruvate Carrier with the Clinical and Histological Features in Lupus Nephritis

International Journal of Nephrology and Renovascular Disease
Huanhuan Zhu, Chen Chen, Luhan Geng, Qing Li, Chengning Zhang, Lin Wu, Bo Zhang, Suyan Duan,* Changying Xing,* Yanggang Yuan* Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University ...
Zhu H, Chen C, Geng L, Li Q, Zhang C, Wu L, Zhang B, Duan S, Xing C, Yuan Y   +9 more
doaj  

Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier [PDF]

Inhibition of mitochondrial pyruvate transport via the mitochondrial pyruvate carrier (MPC) has shown beneficial effects in treating metabolic diseases, certain cancers, various forms of neurodegeneration, and hair loss.
Brookheart, Rita T, Elgendy, Bahaa, Finck, Brian N, Habibi, Mohammad, Hadji, Aymen, Hegazy, Lamees, Kelly, Meredith O, Maram, Lingaiah, McCommis, Kyle S, Michael, Jessica M, Politte, Henry, Srirama, Vaishnavi S   +11 more
core   +2 more sources

Doctor of Philosophy [PDF]

, 2016
dissertationThe discovery of the Mitochondrial Pyruvate Carrier (MPC) began with investigating the role of highly conserved uncharacterized mitochondrial proteins.
Schell, John Charles
core   +3 more sources

Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier. [PDF]

The mitochondrial pyruvate carrier (MPC), of the SLC54 family of solute carriers, has a critical role in eukaryotic energy metabolism by transporting pyruvate, the end-product of glycolysis, into the mitochondrial matrix.

core   +2 more sources

Doctor of Philosophy [PDF]

, 2014
dissertationMitochondria are complex organelles that have important roles in energy production, intermediary metabolism, signal transduction, and apoptosis.
Bricker, Daniel Kevin
core  

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

Molecular Neurodegeneration, 2018
Several molecular pathways are currently being targeted in attempts to develop disease-modifying therapies to slow down neurodegeneration in Parkinson’s disease.
Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca, Patrik Brundin   +5 more
doaj   +1 more source

Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury

Molecular Metabolism
Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains unclear ...
Adam J. Rauckhorst, Gabriela Vasquez Martinez, Gabriel Mayoral Andrade, Hsiang Wen, Ji Young Kim, Aaron Simoni, Claudia Robles-Planells, Kranti A. Mapuskar, Prerna Rastogi, Emily J. Steinbach, Michael L. McCormick, Bryan G. Allen, Navjot S. Pabla, Ashley R. Jackson, Mitchell C. Coleman, Douglas R. Spitz, Eric B. Taylor, Diana Zepeda-Orozco   +17 more
doaj   +1 more source