Results 71 to 80 of about 2,844 (161)

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments [PDF]

, 2022
OBJECTIVE: Metabolomics as an approach to solve biological problems is exponentially increasing in use. Thus, this a pivotal time for the adoption of best practices.
Borcherding, Nicholas, Kraus, Alora S, Pape, Daniel J, Rauckhorst, Adam J, Scerbo, Diego A, Taylor, Eric B   +5 more
core   +3 more sources

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, Volume 117, Issue 5, Page 1199-1208, May 2026.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source

Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy [PDF]

, 2020
[Abstract] Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy.
Bianchi, Katiuscia, Crespo-Leiro, María Generosa, Doménech, Nieves, Eaton, Philip, Eykyn, Thomas R., Fernández-Caggiano, Mariana, Francois, Asvi A., García-Vieites, M., Kamynina, Alisa, Krasemann, Susanne, Morales, Valle, Prysyazhna, Oleksandra   +11 more
core   +1 more source

Mitochondrial Pyruvate Carriers are not Required for Adipogenesis but are Regulated by High-Fat Feeding in Brown Adipose Tissue [PDF]

, 2020
© 2020 The Obesity Society. Objective: The objectives of this study were to assess the role of mitochondrial pyruvate carriers (MPCs) in adipocyte development in vitro and determine whether MPCs are regulated in vivo by high-fat feeding in male and ...
Burrell, Jasmine A., King, William T., Richard, Allison J., Stephens, Jacqueline M.   +3 more
core   +2 more sources

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Monocarboxylate transporters in the brain and in cancer. [PDF]

, 2016
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes.
Falces, J., Payen, V.L., Pellerin, L., Pérez-Escuredo, J., Sboarina, M., Sonveaux, P., Van Hée, V.F.   +6 more
core   +1 more source

Regulation of MPCs and KAT8 During Adipogenesis and Nutritional Regulation [PDF]

, 2020
Obesity is a global epidemic characterized by an expansion of adipose tissue. Adipose tissue, composed of adipocytes and a stromal vascular fraction, is an endocrine organ that regulates whole body homeostasis.
Burrell, Jasmine
core   +2 more sources

Loss of a Functional Mitochondrial Pyruvate Carrier in Komagataella phaffii Does Not Improve Lactic Acid Production from Glycerol in Aerobic Cultivation

Microorganisms, 2023
Cytosolic pyruvate is an essential metabolite in lactic acid production during microbial fermentation. However, under aerobiosis, pyruvate is transported to the mitochondrial matrix by the mitochondrial pyruvate carrier (MPC) and oxidized in cell ...
Ana Caroline de Oliveira Junqueira, Nadielle Tamires Moreira Melo, Nádia Skorupa Parachin, Hugo Costa Paes   +3 more
doaj   +1 more source

Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression

Diabetes, Obesity and Metabolism, Volume 28, Issue S2, Page 31-45, April 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coalesce to drive inflammatory signalling leading to metabolic dysfunction‐associated steatohepatitis (MASH) and fibrosis. Recent clinical
Evangelia E. Tsakiridis, Gregory R. Steinberg   +1 more
wiley   +1 more source