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Mitochondrial Respiration and Oxygen Tension
2017Measurements of respiration and oxygen tension in plant organs allow a precise understanding of mitochondrial capacity and function within the context of cellular oxygen metabolism. Here we describe methods that can be routinely used for the isolation of intact mitochondria, and the determination of respiratory electron transport, together with ...
Daniel S, Shaw +3 more
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Regulation of Mitochondrial Respiration in Liver
1986In studies on the control of mitochondrial respiration carried out in the past 10 years, particular attention has been focussed on cytochrome c oxidase and the adenine nucleotide translocator as rate-controlling steps. On the basis of the observation that the first two phosphorylation sites of the respiratory chain are in near equilibrium with the ...
Verhoeven, A. J. +5 more
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Methanethiol inhibition of mitochondrial respiration
Toxicology and Applied Pharmacology, 1977Abstract Methanethiol and other alkylthiols appear to be at least partly responsible for fetor hepaticus, the unpleasant breath-odor of comatose patients with severe liver disease. We have found that methanethiol strongly inhibits rat liver mitochondrial respiration.
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Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration
Journal of Neurochemistry, 1995Abstract: Dopamine, due to metabolism by monoamine oxidase or autoxidation, can generate toxic products such as hydrogen peroxide, oxygenâderived radicals, semiquinones, and quinones and thus exert its neurotoxic effects. Intracerebroventricular injection of dopamine into rats pretreated with the monoamine oxidase nonselective inhibitor pargyline ...
D, Ben-Shachar, R, Zuk, Y, Glinka
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Bax Impairs Mitochondrial Respiration
Science's STKE, 2000The mechanism by which the proapoptotic protein Bax exerts its effects has not been clear, although it is thought to involve alterations in mitochondrial physiology. Harris et al. report one possible reason why Bax expression is toxic in both yeast and mammalian cells.
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Effect of Ryanodine on Mitochondrial Respiration
Pharmacology, 1992Ryanodine is a pharmacological agent that stimulates calcium leakage into the cytoplasm resulting in an increase in tension. In skeletal muscle, ryanodine acts primarily on the sarcoplasmic reticulum whereas in smooth muscle, the sites of action are less clear.
R M, Levin +4 more
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Action of halothane upon mitochondrial respiration
Archives of Biochemistry and Biophysics, 1971Abstract The inhibitory action of halothane upon respiration was studied with rat liver mitochondria (RLM3), beef heart mitochondria (HBHM), and electron-transport particles (ETP). With intact mitochondrial preparations the oxidation of NADH-linked substrates but not of succinate was markedly suppressed by low concentrations of halothane ( m as ...
R A, Harris +4 more
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Ochratoxin A: Inhibition of Mitochondrial Respiration
Science, 1970Ochratoxin A is a fungal metabolite which induces pathological changes in animals. The toxin was isolated from cultures of Aspergillus ochraceus and purified by thin-layer chromatography. Ochratoxin A and one of its hydrolysis products, dihydroisocoumarin, severely inhibited coupled respiration when applied at low ...
J H, Moore, B, Truelove
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Lead Effects on Corn Mitochondrial Respiration
Science, 1970Oxidation of exogenous nicotinamide-adenine dinucleotide and succinate by corn mitochondria was measured as a function of lead chloride concentration. Lead chloride (50 to 62 micromoles per liter) stimulated oxidation of exogenous reduced nicotinamide-adenine dinucleotide by 174 to 640 percent depending on the reaction mediums, whereas lead chloride ...
D E, Koeppe, R J, Miller
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Mitochondrial respiration not required
Science Signaling, 2019Chondrocytes survive constitutive hypoxia by suppressing mitochondrial respiration.
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