Results 81 to 90 of about 98,042 (158)

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. [PDF]

, 2018
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a
Freedman, Barry I, Hughes, Timothy M, Mahapatra, Gargi, Maldjian, Joseph A, Molina, Anthony JA, Smith, S Carrie, Wagner, Benjamin   +6 more
core  

Living unicellular eukaryote Tetrahymena pyriformis as a model for study of mitochondrial energetics in mammalian cells under conditions of reduced oxidative metabolism. [PDF]

, 2010
Some “animal-like” protozoa are used instead of mammalian cells in diverse investigations. _Tetrahymena pyriformis_ cells in stationary phase of growth and washed from oxidative substrates (_T.pyriformis_) function under conditions of ...
Elena Mokhova
core   +1 more source

Flux control of cytochrome c oxidase in human skeletal muscle [PDF]

, 2000
In the present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX have been determined in human saponin-permeabilized muscle fibers. In the presence of the
Attardi, Giuseppe, Elger, Christian E., Kudin, Alexei, Kunz, Wolfram S., Vielhaber, Stefan, Villani, Gaetano   +5 more
core   +1 more source

Identity and Function of a Cardiac Mitochondrial Small Conductance Ca2+-Activated K+ Channel Splice Variant [PDF]

, 2017
We provide evidence for location and function of a small conductance, Ca2+-activated K+ (SKCa) channel isoform 3 (SK3) in mitochondria (m) of guinea pig, rat and human ventricular myocytes. SKCa agonists protected isolated hearts and mitochondria against
Aldakkak, Mohammed, Camara, Amadou K. S., Kwok, Wai-Meng, Stowe, David F., Yang, MeiYing   +4 more
core   +1 more source

Proteasome Lid Bridges Mitochondrial Stress with Cdc53/Cullin1 NEDDylation Status [PDF]

, 2019
Cycles of Cdc53/Cullin1 rubylation (a.k.a NEDDylation) protect ubiquitin-E3 SCF (Skp1-Cullin1-F-box protein) complexes from self-destruction and play an important role in mediating the ubiquitination of key protein substrates involved in cell cycle ...
Bramasole, L., Gefen, E., Glickman, M. H., Gurevich, S., Jimenez-Morales, D., Johnson, J., Klein, Y., Krogan, N. J., Panat, N., Pick, E., Radzinski, M., Reichmann, D., Reis, N., Rinaldi, T., Sinha, A.   +14 more
core   +1 more source

Microchambers with Solid-State Phosphorescent Sensor for Measuring Single Mitochondrial Respiration

Sensors, 2016
It is now well established that, even within a single cell, multiple copies of the mitochondrial genome may be present (genetic heteroplasmy). It would be interesting to develop techniques to determine if and to what extent this genetic variation results
Ted D. Pham, Douglas C. Wallace, Peter J. Burke   +2 more
doaj   +1 more source

Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function [PDF]

, 2014
The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen ...
Aon, Miguel A., Cortassa, Sonia del Carmen, Kembro, Jackelyn Melissa   +2 more
core   +2 more sources

Mitochondrial fatty acid synthesis and respiration

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles bacterial fatty acid synthesis (FAS) type II, which uses discrete, nuclearly encoded proteins. Experimental evidence, obtained mainly through using yeast as a model system, indicates that
Hiltunen, J. Kalervo, Autio, Kaija J., Schonauer, Melissa S., Kursu, V.A. Samuli, Dieckmann, Carol L., Kastaniotis, Alexander J.   +5 more
openaire   +2 more sources

Menstrual cycle influence on skeletal muscle mitochondrial respiration in humans

Physiological Reports
The menstrual cycle influences function in various tissues in the body. We sought to determine if menstrual cycle phase could influence mitochondrial function in skeletal muscle in females.
W. Bradley Nelson, Brandon S. Pfeifer, Ashley R. Lovell, Erik D. Marchant, Briell V. Mitchell, Erin L. Atkinson, Trevor L. Murphy, Sydney L. Poulsen, Jay R. K. Baird, Chad R. Hancock, Robert D. Hyldahl   +10 more
doaj   +1 more source

Differential Effects of Buffer pH On Ca\u3csup\u3e2+\u3c/sup\u3e-Induced ROS Emission with Inhibited Mitochondrial Complexes I and III [PDF]

, 2015
Excessive mitochondrial reactive oxygen species (ROS) emission is a critical component in the etiology of ischemic injury. Complex I and complex III of the electron transport chain are considered the primary sources of ROS emission during cardiac ...
Aldakkak, Mohammed, Camara, Amadou K. S., Lindsay, Daniel P., Lubbe, Ryan, Stowe, David F.   +4 more
core   +1 more source