Results 81 to 90 of about 1,557,014 (330)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury*

Journal of Biological Chemistry, 2004
Reactive oxygen species (ROS) play a key role in promoting mitochondrial cytochrome c release and induction of apoptosis. ROS induce dissociation of cytochrome c from cardiolipin on the inner mitochondrial membrane (IMM), and cytochrome c may then be ...
Kesheng Zhao, Guo-Min Zhao, Dun-Li Wu, Y. Soong, A. Birk, P. Schiller, H. Szeto   +6 more
semanticscholar   +1 more source

Disruption of Mitochondrial Respiration Inhibits Volume-Regulated Anion Channels and Provokes Neuronal Cell Swelling

, 1998
Hypoxia and inhibitors of mitochondrial respiration impair the regulatory volume decrease (RVD) of cerebellar granule neurons after hypotonic swelling. RVD is linked to the opening of volume-regulated anion channels (VRACs).
Inger Lauritzen, Michel Lazdunski, Amanda J. Patel, Eric Honoré   +3 more
core   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Effects of hyperbaric oxygen therapy on the liver after injury caused by the hepatic ischemia-reperfusion process [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To evaluate the effects of hyperbaric oxygen on rats submitted to hepatic ischemia and reperfusion. METHODS: Twenty-three Wistar rats were divided at random into 3 groups: SHAM, rats submitted to surgical and anesthetic stress without induction ...
Marina Rodrigues Garcia da Silveira, Maria Rita Margarido, José Carlos Vanni, Ricardo Nejo Junior, Orlando de Castro-e-Silva   +4 more
doaj   +2 more sources

Corn Mitochondrial Swelling and Contraction—an Alternate Interpretation [PDF]

Plant Physiology, 1974
Mitochondria isolated from 3-day-old etiolated corn shoots (Zea mays L.) can be categorized into three separate groups, each group characteristic of the cell type from which the mitochondria were isolated. Phloem sieve tubes and some adjacent parenchyma cells contain mitochondria that have few cristae and little amorphous matrix.
C, Malone, D E, Koeppe, R J, Miller
openaire   +2 more sources

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening.

Cell Stem Cell
Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis. Our research identifies the transcription factor Nynrin as a crucial regulator of HSC maintenance by modulating mitochondrial function. Nynrin is highly expressed in HSCs under
Chengfang Zhou, Mei Kuang, Yin Tao, Jian-Ming Wang, Yu Luo, Ying-Hao Fu, Zhe Chen, Yuanyuan Liu, Zhigang Li, Weiru Wu, Li Wang, Ying Dou, Jun-Ping Wang, Yu Hou   +13 more
semanticscholar   +1 more source

Local vs nonlocal models for mitochondria swelling.

, 2021
In this paper, we consider deterministic, continuous, nonlocal models for the mitochondrial permeability transition, i.e. mitochondrial swelling. Based on seminal papers [1], [2], [3], [5] and the book [4], in which ODE-PDE and PDE-PDE local models for ...
Efendiyev, M.A., Muradova, A., Muradov, N., Zischka, H.   +3 more
core  

Proton NMR relaxometry as a useful tool to evaluate swelling processes in peat soils [PDF]

, 2010
Dramatic physical and physico-chemical changes in soil properties may arise due to temperature and moisture variations as well as swelling of soil organic matter (SOM) under constant conditions.
As, H., van, Jaeger, F., Shchegolikhina, A., Schaumann, G.   +3 more
core   +1 more source