Results 71 to 80 of about 1,557,014 (330)
Pharmaceutical Sciences, 2016 Background: Although several cases of methimazole-induced liver injury are reported, but there is no clear idea on the mechanism of methimazole hepatotoxicity. N-methyl thiourea (NMT) is a postulated hepatotoxic metabolite for methimazole.
Hossein Niknahad 1,2, Akram Jamshidzadeh 1,2, Reza Heidari 1 * , Narges Abdoli 3, Mohammad Mehdi Ommati 4, Faezeh Jafari 2, Mahdi Zarei 2, Behnam Asadi 2
doaj +1 more source
CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression
Advanced Science, EarlyView.A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao +27 more
wiley +1 more source
Effects of hyperbaric oxygen therapy as hepatic preconditioning in rats submitted to hepatic ischemia/reperfusion injury [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE:To analyze the role of hyperbaric oxygen therapy as hepatic preconditioning in rats submitted to hepatic ischemia and reperfusion.METHODS:Wistar rats were randomly divided into three groups: SHAM, rats submitted to surgical stress without hepatic
Daniele Moraes Losada +5 more
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Advanced Science, EarlyView.This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
eLife, 2013 A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown.
Jason Karch +11 more
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Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Advanced Science, EarlyView.Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen +5 more
wiley +1 more source
Эпилепсия и пароксизмальные состояния, 2016 Objective. Mitochondrial injury plays a central role in neuronal death following ischemic stroke. In the present study, we investigated effects of ethylmethylhydroxypyridine succinate on a microstroke-induced mitochondria swelling, a hallmark of ...
R. A. Afzalov +4 more
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Mitochondrial Swelling and Incipient Outer Membrane Rupture in Preapoptotic and Apoptotic Cells
The Anatomical Record, 2012 Outer mitochondrial membrane (OMM) rupture was first noted in isolated mitochondria in which the inner mitochondrial membrane (IMM) had lost its selective permeability.
A. Sesso +7 more
semanticscholar +1 more source
Effect of spermine on mitochondrial glutathione release.
, 1993 Spermine prevents glutathione release induced in rat liver mitochondria by the combined addition of Ca2+ and phosphate. Spermine also inhibits mitochondrial swelling, membrane potential decrease, oxygen uptake and [14C] sucrose entry stimulated by the ...
RIGOBELLO, MARIA PIA +3 more
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