Фармакокинетика и Фармакодинамика, 2022 Hemantane (N-adamant-2-yl-hexamethylenimine hydrochloride) is an antiparkinsonian drug with a multicomponent mechanism of action, including a modulating effect on the activity of dopamine and serotonergic mediator systems, a selective inhibitory effect ...
E. A. Anisina +4 more
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DNA Barcoding for Delimitation of Putative Mexican Marine Nematodes Species
Diversity, 2020 Nematode biodiversity is mostly unknown; while about 20,000 nematode species have been described, estimates for species diversity range from 0.1 to 100 million.
Arely Martínez-Arce +2 more
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Regulation of the mitochondrial permeability transition pore and its effects on aging
Microbial Cell, 2020 Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems.
Damiano Pellegrino-Coppola
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Functional activity of permeability transition pore in energized and deenergized rat liver mitochondria [PDF]
The Ukrainian Biochemical Journal, 2020 Permeability transition pore (mPTP) opening was studied under energized and deenergized conditions in rat liver mitochondria, and the effect of membrane depolarization on mPTP activity was evaluated.
O. V. Akopova +2 more
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The Effect of Treadmill Exercise on Expression of α-synuclein and miRNA in MPTP Induced-mouse Models of Parkinson’s Disease [PDF]
운동과학, 2017 PURPOSE The goal of this study was to demonstrate whether treadmill exercise have an effect on the level of α-synuclein and microRNA (miRNA) in striatum of Parkinson’s Disease (PD) induced mouse models.
Sue-Jin Moon +3 more
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Acta Pharmaceutica, 2022 Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral ...
Casanova Yaquelyn +2 more
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Asymmetric Opening of Mitochondrial Permeability Transition Pore in Mouse Brain Hemispheres: A Link to the Mitochondrial Calcium Uniporter Complex [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 The prolonged entry of large amounts of calcium into the mitochondria through the mitochondrial calcium uniporter complex (MCUC) may cause the permeability transition pore (mPTP) to open, which contributes to the pathogenesis of several diseases.
Mehvish Batool +2 more
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Neuroprotective Effects and Related Mechanisms of Echinacoside in MPTP-Induced PD Mice
Neuropsychiatric Disease and Treatment, 2021 Zhen-Nian Zhang,1,* Zhen Hui,1,* Chang Chen,1 Yan Liang,1 Li-Li Tang,1 Su-Lei Wang,1 Cheng-Cheng Xu,1 Hui Yang,1 Jing-Si Zhang,2 Yang Zhao1 1Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese ...
Zhang ZN +9 more
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Effect of nicotine on the energy metabolism of substantia nigra cells in mptp-induced Parkinson’s disease [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting millions globally, with no current cure despite extensive research efforts.
Nikoloz Zhgenti +6 more
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Antioxidants, 2020 Hericium erinaceus, a valuable pharmaceutical and edible mushroom, contains potent bioactive compounds such as H. erinaceus mycelium (HEM) and its derived ethanol extraction of erinacine A, which have been found to regulate physiological functions in our
Kam-Fai Lee +11 more
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