Results 11 to 20 of about 39,988 (211)

Zonisamide Attenuates MPTP Neurotoxicity in Marmosets

Journal of Pharmacological Sciences, 2010
.: MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces parkinsonism in humans and animals. The effects of zonisamide on dopamine neurons were studied in MPTP-treated common marmosets (Callithrix jacchus).
Mohammed Emamussalehin Choudhury, Takashi Moritoyo, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Madoka Kubo, Seiji Matsuda, Masahiro Nomoto   +7 more
doaj   +2 more sources

Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP

Journal of Pharmacological Sciences, 2009
.: The effect of zonisamide, an antiepileptic agent with anti-parkinsonian effects, was studied on dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 mice and common marmosets. Groups of mice (n = 8 – 9) were treated with:
Hayato Yabe, Mohammed Emamussalehin Choudhury, Madoka Kubo, Noriko Nishikawa, Masahiro Nagai, Masahiro Nomoto   +5 more
doaj   +2 more sources

Restoration of MPTP-induced deficits by exercise and Milmed® co-treatment [PDF]

PeerJ, 2014
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces permanent neurochemical and functional deficits. Following the administration of either two or four injections of the dopamine neurotoxin, MPTP, at a dose of 40 mg/kg, C57/BL6 mice were given ...
Trevor Archer, Danilo Garcia, Anders Fredriksson   +2 more
doaj   +4 more sources

Atherosclerotic-dose TMAO accentuates redox imbalances and motor dysfunctions in a MPTP mouse model of Parkinson’s disease [PDF]

Frontiers in Aging Neuroscience
Parkinson’s Disease (PD) involves the loss of dopaminergic neurons and the formation of Lewy bodies consisting of alpha-synuclein (αSin) aggregates. Trimethylamine N-oxide (TMAO), a gut microbiota metabolite, has emerged as a molecule of interest due to ...
Paul-Ştefan Panaitescu, Ioana Bâldea, Vlad Alexandru Toma, Vlad Alexandru Toma, Alexandra-Maria Nuţu, Claudia-Andreea Moldoveanu, Claudia-Andreea Moldoveanu, Claudia-Andreea Moldoveanu, Alexandra Sevastre-Berghian, Ana-Maria Vlase, Irina Camelia Haranguş, Carmen Costache, Simona Clichici, Gabriela Adriana Filip   +13 more
doaj   +2 more sources

CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation via suppressing mitophagy in MPTP/MPP+ PD model

Ecotoxicology and Environmental Safety
The discovery of MPTP, an industrial chemical and contaminant of illicit narcotics, which causes parkinsonism in humans, non-human primates and rodents, has led to environmental pollutants exposure being convicted as key candidate in Parkinson’s disease (
Yixian Ren, Xian Wu, Tianyao Bai, Nanfei Yang, Yuyu Yuan, Lingling Xu, Yue Wen, Ying Wen, Zhi Wang, Liping Zhou, Fei Zou, Wenjun Li   +11 more
doaj   +2 more sources

Chronic administration of MPTP to marmosets.

Advances in neurology, 1990
Chronic administration of MPTP to ...
Albanese, Alberto, Altavista, Mc, Gozzo, S, Rossi, P, Colosimo, C, Bentivoglio, Anna Rita, Perretta, G, Elia, M, Monaco, V, Macchi, G.   +9 more
openaire   +3 more sources

A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson’s disease [PDF]

, 2015
Parkinson's disease (PD) is an age-associated neurodegenerative disorder hallmarked by a loss of mesencephalic dopaminergic neurons. Accurate recapitulation of the PD movement phenotype in animal models of the disease is critical for understanding ...
Geldenhuys, Werner, Pienaar, Ilse, Young, Jesse, Dean E. Dluzen, Werner J. Geldenhuys, Tamara L. Guseman, Ilse S. Pienaar, Jesse W. Young, Dluzen, Dean, Guseman, Tamara   +9 more
core   +2 more sources

Mechanism of the neurotoxicity of MPTP [PDF]

FEBS Letters, 1990
This review summarizes advances in our understanding of the biochemical events which underlie the remarkable neurotoxic action of MPTP (1‐methyl‐4‐phenyl‐1‐1,2,3,6‐tetrahydropyridine) and the parkinsonian symptoms it causes in primates. The initial biochemical event is a two‐step oxidation by monoamine oxidase B in glial cells to MPP+ (1‐methyl‐4 ...
Singer, Thomas P., Ramsay, Rona R.
openaire   +2 more sources

Mechanism of Autophagy Regulation in MPTP-Induced PD Mice via the mTOR Signaling Pathway by Echinacoside

Neuropsychiatric Disease and Treatment, 2021
Zhen-Nian Zhang,1,* Zhen Hui,1,* Chang Chen,1 Yan Liang,1 Li-Li Tang,1 Su-Lei Wang,1 Cheng-Cheng Xu,1 Hui Yang,1 Yang Zhao,1 Jing-Si Zhang2 1Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese ...
Zhang ZN, Hui Z, Chen C, Liang Y, Tang LL, Wang SL, Xu CC, Yang H, Zhao Y, Zhang JS   +9 more
doaj  

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets [PDF]

, 1992
The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets.
Smith, L. A., Jähnig, P., Marsden, C. D., Jenner, P., Lange, Klaus W., Löschmann, P. A., Lance A. Smith, Peter Jenner, Peter Jähnig, C. David Marsden, Peter-A. Löschmann, Klaus W. Lange   +11 more
core   +1 more source