Results 21 to 30 of about 39,988 (211)

Neuroprotection by dopamine agonists [PDF]

, 1994
Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents.
Rausch, W. D., Naumann, M., Riederer, P., Oestreicher, E., Lange, Klaus W., Gsell, W.   +5 more
core   +1 more source

Photobiomodulation Mitigates Cerebrovascular Leakage Induced by the Parkinsonian Neurotoxin MPTP

Biomolecules, 2019
The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is commonly used to model Parkinson’s disease (PD) as it specifically damages the nigrostriatal dopaminergic pathway.
Mia San Miguel, Kristy L. Martin, Jonathan Stone, Daniel M. Johnstone   +3 more
doaj   +1 more source

Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway

Biomolecules, 2022
Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy for Parkinson’s disease (PD). PD is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta ...
Hung-Te Hsu, Ya-Lan Yang, Wan-Hsuan Chang, Wei-Yu Fang, Shu-Hung Huang, Shah-Hwa Chou, Yi-Ching Lo   +6 more
doaj   +1 more source

The Effect of Aqueous Extract of Rosemary )Rosmarinus officinalis) on Parkinson\'s Disease Induced by MPTP in Male Mice

Journal of Ardabil University of Medical Sciences, 2023
Background & objectives: Parkinson’s disease is a disorder that causes progressive degeneration of neurons, and oxidative stress is increasingly implicated as a factor that contributes to its pathophysiology.
Mohammad Amani, Ali Hosseininia, Hamid Sheikhkanloui Milan   +2 more
doaj  

Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F]FE-PE2I Positron Emission Tomography Analysis Study

Frontiers in Pharmacology, 2020
Fas-associated factor 1 (FAF1), a Fas-binding protein, is implicated in neuronal cell death in Parkinson’s disease (PD). We examined the effects of a novel FAF1 inhibitor, KM-819, in dopaminergic neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (
Hyun Soo Park, Hyun Soo Park, Yoo Sung Song, Byung Seok Moon, Sung-Eun Yoo, Jae Moon Lee, Yeon-Tae Chung, Eunhee Kim, Byung Chul Lee, Byung Chul Lee, Byung Chul Lee, Sang Eun Kim, Sang Eun Kim, Sang Eun Kim   +13 more
doaj   +1 more source

Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease

Basic and Clinical Neuroscience, 2022
Introduction: Parkinson disease (PD) results from the destruction of dopaminergic neurons in the brain. This study aimed to investigate the protective effects of natural antioxidants such as caffeic acid phenethyl ester (CAPE) to maintain these neurons ...
Khojasteh Rahimi Jaberi, Manouchehr Safari, Vahid Semnani, Hamid Reza Sameni, Sam Zarbakhsh, Laya Ghahari   +5 more
doaj  

Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson’s disease model by AMPK-mediated autophagy

, 2022
Parkinson’s disease (PD) is a well-known neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, and oxidative stress and neuroinflammation are also associated with the pathogenesis of PD.
Jiali Xie, Yao Liu, Jian Tan, Dong Chang, Kailiang Huang, Juan Wan, Shanqing Yi, Yijiang Gao, Shuangxi Chen, Heng Wu   +9 more
core   +1 more source

The MPTP Story

Journal of Parkinson’s Disease, 2017
The identification of MPTP, a relatively simple compound which causes selective degeneration of the substantia nigra after systemic administration, has had an a significant impact on the understanding and treatment of Parkinson’s disease (PD) over the last 30 years.
openaire   +3 more sources

The Mitochondrial Permeability Transition Pore—Current Knowledge of Its Structure, Function, and Regulation, and Optimized Methods for Evaluating Its Functional State

Cells, 2023
The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-selective membrane pore with a wide range of functions. Although the MPTP has been studied for more than 50 years, its molecular structure remains unclear.
René Endlicher, Zdeněk Drahota, Kateřina Štefková, Zuzana Červinková, Otto Kučera   +4 more
doaj   +1 more source

Inhibition of Bcl-2 sensitizes mitochondrial permeability transition pore (MPTP) opening in ischemia-damaged mitochondria. [PDF]

PLoS ONE, 2015
Mitochondria are critical to cardiac injury during reperfusion as a result of damage sustained during ischemia, including the loss of bcl-2. We asked if bcl-2 depletion not only leads to selective permeation of the outer mitochondrial membrane (MOMP ...
Qun Chen, Haishan Xu, Aijun Xu, Thomas Ross, Elizabeth Bowler, Ying Hu, Edward J Lesnefsky   +6 more
doaj   +1 more source