PET analysis of dopaminergic neurodegeneration in relation to immobility in the MPTP-treated common marmoset, a model for Parkinson's disease. [PDF]
PLoS ONE, 2012 BACKGROUND: Positron Emission Tomography (PET) measurement was applied to the brain of the common marmoset, a small primate species, treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Kiyoshi Ando +8 more
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Preserved behavioral responses in MPTP-treated ASK1−/− mice compared to MPTP-treated wild-type mice.
, 2013 (A) Performance on the Rotarod test one day post-MPTP.
Teresa W. Chan (335663) +10 more
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Cardiac tyrosine hydroxylase activation and MB-COMT in dyskinetic monkeys
Scientific Reports, 2021 The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing ...
Lorena Cuenca-Bermejo +8 more
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Estratégias ambientais como alternativas para a prevenção de sintomas de ansiedade e depressão em um modelo experimental da doença de Parkinson em ratos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2011A doença de Parkinson (DP) é uma doença multifatorial que se caracteriza pela degeneração ...
Savoldi, Robson
core
Neurobiology of Disease, 2003 The neuroprotective efficacy of the propargylamine TCH346 was studied in the primate model of Parkinson's disease, the bilaterally MPTP-treated monkey. Male rhesus monkeys received 2.5 mg MPTP into the left carotid artery and, 8 weeks later, 1.25 mg MPTP
Gerda Andringa +7 more
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Фармакокинетика и Фармакодинамика, 2016 Antiparkinsonian, anti-inflammatory and analgesic activity of ADK-1058, a metabolite of hemantane, was investigated in comparison with hemantane at the effective dose of 20 mg/kg. ADK-1058 exhibits a minor antiparkinsonian effect by reducing the severity
I. G. Kapitsa +4 more
doaj
Mitochondrial permeability transition pore as a selective target for anti-cancer therapy
Frontiers in Oncology, 2013 Mitochondrial outer membrane permeabilization (MOMP) is the ultimate step in dozens of lethal apoptotic signal transduction pathways which converge on mitochondria.
Dong Hoon eSuh +6 more
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IBRO Neuroscience Reports, 2022 The potential of Se to alleviate pain associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity was investigated.Swiss mice were intraperitoneally injected with MPTP (20 mg/kg) 4 times with an interval of 2 h in 1 day ...
Patrick Oluwole Abolarin +5 more
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Prejuízos olfativos e cognitivos em modelos da Doença de Parkinson em ratos: participação de mecanismos adenosinérgico e dopaminérgico [PDF]
, 2005 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciênicas Biológicas. Programa de Pós-Graduação em FarmacologiaEmbora a Doença de Parkinson (DP) seja caracterizada como um distúrbio do movimento, muitos estudos têm demonstrado que ...
Prediger, Rui Daniel Schröder
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Delayed Exercise-Induced Functional and Neurochemical Partial Restoration Following MPTP
, 2011 In two experiments, MPTP was administered to C57/BL6 mice according to a single-dose weekly regime (MPTP: 1 x 30 mg/kg on the fifth day of the week, Friday, over 4 weeks) with vehicle group (Vehicle: 1 x 5 ml/kg) treated concurrently. Exercise schedules (
Anders Fredriksson +5 more
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