Results 61 to 70 of about 39,988 (211)

Design and synthesis of 18F-labeled neurotoxic analogs of MPTP

, 2019
We report on the synthesis of two fluorine-18 labeled analogs of l-methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine (MPTP). A piperidyl triazene was fluorinated to produce [18F]-l-methyl-4- (2-fluorophenyl)-l, 2, 3, 6-tetrahydropyridine (2'-F-MPTP, 12) in ...
Sayre, Lawrence M., Arora, Pramod K., Terris, Andrew H., Berridge, Marc S., Harik, Sami I., Riachi, Naji J.   +5 more
core   +1 more source

Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?

Journal of Neuroinflammation, 2018
Background Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related to the progressive neurodegeneration in Parkinson’s disease (PD).
Ana-Luisa Gil-Martínez, Lorena Cuenca, Consuelo Sánchez, Cristina Estrada, Emiliano Fernández-Villalba, María Trinidad Herrero   +5 more
doaj   +1 more source

Effects of Hemantane upon the level of lipid peroxidation in brain in experimental parkinsonian syndrome

Фармакокинетика и Фармакодинамика, 2016
In two animaL modeLs of parkinsonian syndrome - induced by 1-methyL-4-phenyL-1,2,3,6-tetrahydropiridine (MPTP) in C57BL/6 mice and 6-hydroxidopamine (6-OHDA) in rats noveL antiparkinsonian drug hemantane was shown to reduce the increase of brain LeveL of
E. A. Ivanova, I. G. Kapitsa, N. N. Zolotov, E. A. Valdman, A. V. Nepoklonov, K. N. Kolyasnikova, T. A. Voronina   +6 more
doaj  

MPTP Mouse Models of Parkinson's Disease: An Update

Journal of Parkinson’s Disease, 2011
Among the most widely used models of Parkinson's disease (PD) are those that employ toxins, especially 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Gloria E. Meredith, David J. Rademacher
doaj   +1 more source

MPTP induced astrogilal activation is suppressed in ASK1^−/− mice.

, 2013
(A, B) Immunohistochemistry for GFAP in nigral (SNc) and striatal (ST) sections. Scale bar = 100 µm.
Teresa W. Chan (335663), Eunsung Junn (335666), Xin Zhao (71840), Dwight C. German (335665), Kang-Woo Lee (335658), Patricia K. Sonsalla (335664), Hidenori Ichijo (185177), Hilary Grosso (335661), M. Maral Mouradian (335668), Joo-Young Im (335660), Won Hee Jang (335662)   +10 more
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Biochemical Reactions Leading to Parkinsonian Symptoms Elicited by MPTP

, 1990
Expression of the neurotoxicity of MPTP and of its analogs-is initiated by a two-step oxidation of the corresponding pyridinium, catalyzed by monoamine oxidase (MAO) A or B.
Rona R. Ramsay, Thomas P. Singer, Singer, Thomas P., Ramsay, Rona R., Ramsay, Rona R.; id_orcid   +4 more
core   +1 more source

Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway

, 2018
Ming Hu, Fangming Li, Weidong Wang Department of Neurology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disease which is characterized by the ...
Li F, Hu M, Wang W
core  

Amphetamine-induced circling behaviour in MPTP-lesioned mice

, 1985
This study was designed to examine the effect of intra-striatal administration of MPTP on (+)-amphetamine-induced circling behaviour in mice. The results demonstrate that (+)-amphetamine elicits circling behaviour in MPTP-lesioned animals.
Charles E Troxel, Yiu K Fung
core   +1 more source

The effects of oxidative stress and intracellular calcium on mitochondrial permeability transition pore formation in equine spermatozoa

FASEB BioAdvances
The in vitro storage of stallion spermatozoa for use in artificial insemination leads to oxidative stress and imbalances in calcium homeostasis that trigger the formation of the mitochondrial permeability transition pore (mPTP), resulting in premature ...
Zamira Gibb, Robert J. Aitken, Alecia R. Sheridan, Brandan Holt, Stephanie Waugh, Aleona Swegen   +5 more
doaj   +1 more source

Properties of 3H-MPTP binding sites in human blood platelets

, 1986
Our study demonstrates that 3H-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (3H-MPTP) specifically binds to platelet membrane sites in humans. This specific, high affinity and saturable binding has properties similar to those of 3H-MPTP binding to rat ...
BONUCCELI U, BAJOREK M, DEL ZOMPO, MARIA, Del Zompo M, ARNONE M, CORSINI G. U., BONUCCELLI, UBALDO, CORSINI, GIOVANNI UMBERTO, BERNARDI F, MAGGIO R   +9 more
core   +1 more source