Results 71 to 80 of about 39,988 (211)

The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease.

Folia Histochemica et Cytobiologica, 2010
Parkinson's disease (PD) is the second most common neurodegenerative disorder marked by cell death in the Substantia nigra (SN). Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the phospholipid fraction of the brain and is ...
Gokhan Akkoyunlu, Ozlem Ozsoy, Yasemin Seval-Celik, Gamze Tanriover, Feyza Savcioglu, Gulay Hacioglu, Necdet Demir, Aysel Agar   +7 more
doaj   +1 more source

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

Parkinson's Disease, 2011
Nigrostriatal damage is increased in males relative to females. While estrogen is neuroprotective in females, less is known about potential protective effects of testosterone in males.
Eleni Antzoulatos, Michael W. Jakowec, Giselle M. Petzinger, Ruth I. Wood   +3 more
doaj   +1 more source

MPTP impairs dopamine D1 receptor-mediated survival of newborn neurons in ventral hippocampus to cause depressive-like behaviors in adult mice

Frontiers in Molecular Neuroscience, 2016
Parkinson’s disease is characterized by motor symptoms with depression. We evaluated the influence of dopaminergic depletion on hippocampal neurogenesis process to explore mechanisms of depression production.
Tingting Zhang, Tingting Zhang, Juan Hong, Juan Hong, Tingting Di, Ling Chen, Ling Chen   +6 more
doaj   +1 more source

MPTP: Advances from an Evergreen Neurotoxin

, 2021
Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson’s disease (PD) research.
Palmas, Maria Francesca, Barcia, Carlos, Maria Francesca Palmas, María-Trinidad Herrero, Anna R. Carta, Herrero, María-Trinidad, Carlos Barcia, Carta, Anna R., Cuenca-Bermejo, Lorena, Augusta Pisanu, Lorena Cuenca-Bermejo, Pisanu, Augusta   +11 more
core   +1 more source

mPTP Analysis

, 2019
File contains the 90% similarity threshold with 75% taxon coverage .fasta alignment file and the maximum likelihood tree from RAxML used to construct the mPTP ...
Diarmaid O' Foighil (6270644), O' Foighil, Diarmaid, Amanda E. Haponski (3191694), Haponski, Amanda E.   +3 more
core   +1 more source

Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice

Journal of Parkinson’s Disease
Background: MPTP and paraquat are two compounds that have been used to model Parkinson’s disease in mice. Previous studies in two non-traditional strains of mice have shown that a single dose of MPTP can induce changes in body temperature, while the ...
Yun Jiao, Yuchen Dou, Georgina Lockwood, Amar Pani, Richard Jay Smeyne   +4 more
doaj   +1 more source

Efecto del inhibidor de amida hidrolasa de ácidos grasos en el daño neuronal dopaminérgico inducido por MPTP

Neurología, 2019
Resumen: Introducción: La enfermedad de Parkinson) es un desorden neurodegenerativo caracterizado por problemas de equilibro, rigidez muscular y lentitud para realizar movimiento, debido a la pérdida de neuronas dopaminérgicas de la sustancia nigra pars
J.M. Viveros-Paredes, R.E. Gonzalez-Castañeda, A. Escalante-Castañeda, A.R. Tejeda-Martínez, F. Castañeda-Achutiguí, M.E. Flores-Soto   +5 more
doaj   +1 more source

Characterization and localization of cytochrome P450 mediated metabolism of MPTP to nor-MPTP in mouse brain: relevance to Parkinson's disease

, 2001
1-Methyl, 4-phenyl,l,2,5,6,tetrahydropyridine (MPTP) is a dopaminergic toxin which produces Parkinson's disease-like symptoms in primates and dopaminergic cell loss in mice.
Upadhya, Sudarshan C., Boyd, Michael R., Ravindranath, Vijayalakshmi, Michael R. Boyd, Vijayalakshmi Ravindranath, Sudarshan C. Upadhya   +5 more
core   +1 more source

Effect of epigallocatechin gallate on the spermatozoa quality of rats (Rattus norvegicus) exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Bulgarian Journal of Veterinary Medicine
Environmental exposure to neurotoxic compounds is known to impair reproductive function, particularly by reducing sperm quality through oxidative stress and mitochondrial dysfunction. This study aimed to evaluate the protective effect of epigallocatechin
D. P. Wahyudanto, Budiarto, S. Susilowati, Widjiati, S. P. Madyawati, K. Rachmawati, P. Nugraha, V. F. Hendrawan , D. Rahmawati   +8 more
doaj   +1 more source

Primate-rodent 3H-MPTP binding differences, and biotransformation of MPTP to a reactive intermediate in vitro

, 1986
Specific binding of 3H-MPTP to brain homogenates is displaced predominantly by MAO-A inhibitor clorgyline in rat, and by MAO-B inhibitor deprenyl in monkey.
DEL ZOMPO, MARIA, PINTUS S, PICCARDI MP, BOCCHETTA, ALBERTO, CORSINI GU   +4 more
core