Results 91 to 100 of about 39,988 (211)
RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION [PDF]
, 2013 Parkinson’s disease (PD) is a progressive debilitating neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. As the disease progresses there is a loss of dopamine (DA) neurons in the substantia nigra
Subramanian, Krishna
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The c-Abl inhibitor INNO-406 protects against MPTP-induced loss of DA neurons.
, 2013 INNO-406 (10 mg/kg/i.p for one week prior to MPTP, 4×20 mg, and one week after MPTP treatment) protects (A–D) substantia nigra DA neurons and (E–H) striatal DA terminals from MPTP-induced toxicity.
Shinya Kimura (247648) +8 more
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, 2013 Photomicrographs from VMB sections stained with Fluoro-Jade C (left and middle panels) and Mac-1 antibody (right panels). PBS controls (PBS/none) exhibit an absence of Fluoro-Jade C stained dead neurons on days 2 and 7, and only faint Mac-1 ...
Ashley D. Reynolds (37627) +10 more
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IN19-mediated neuroprotection in a chronic MPTP/P injection model.
, 2012 A, The effect of IN19 on neurodegeneration after MPTP/P injections. Brain sections, including the SN (upper row) or CPu (lower row), from wild-type mice that were injected or not injected with MPTP/P, in the presence or absence of IN19, were ...
Hirofumi Sudo (125003) +8 more
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Differential Effects of Carboxyfullerene on Mpp+/Mptp-Induced Neurotoxicity
, 2009 The effects of carboxyfullerene on a well-known neurotoxin, 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite 1- methyl-4-phenyl-pyridinium (MPP+) were investigated. In chloral hydrate- anesthetized rats, cytosolic cytochrome
LIN, MAAN-YUH;YANG, CHIH-HSIN +1 more
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Angiogenin does not prevent MPTP-induced depletion of dopamine and its metabolites in the striatum.
, 2013 Three weeks after MPTP or saline injections, AAV2-GFP and AAV2-Ang-injected mice were sacrificed and striatal tissue immediately removed and frozen for HPLC. DA and its metabolites, DOPAC and HVA, were analyzed by HPLC.
Trent U. Steidinger (284605) +4 more
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BiomoleculesBone is a dynamic organ with an active metabolism and high sensitivity to mitochondrial dysfunction. The mitochondrial permeability transition pore (mPTP) is a low-selectivity channel situated in the inner mitochondrial membrane (IMM), permitting the ...
Xiting Zhu +6 more
doaj +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2015 Background and Objective: Parkinson disease (PD) is the second most common neurologic disorder that results following degeneration of dopaminergic neurons in the pars compacta of substintia nigra (SNc). The 1-methyl-1,2,3,6-tetrahydropiridine (MPTP) is a
Shahi S +5 more
doaj
, 2020 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin commonly used to produce an animal model of Parkinson's disease. Previous studies have suggested a critical role for neuronal nitric oxide (NO) synthase-(nNOS-) derived NO in the ...
Kai-Ping N Chow +4 more
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