Results 31 to 40 of about 39,988 (211)

Neuroprotective effect of valsartan versus pramipexole on mouse model of MPTP-induced Parkinson’s disease

Research Results in Pharmacology
Introduction: Parkinson’s disease is the second most common complex progressive neurodegenerative disease after Alzheimer’s disease. Tremor, stiffness, and bradykinesia are common symptoms, additionally to postural instability as the condition advances ...
Asmaa Abdulwahab Ahmed, Hayder Ridha-Salman, Haitham Mahmood Kadhim, Elaf S.M Khafaja   +3 more
doaj   +1 more source

TOXOPATHOLOGICAL EFFECT OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON THE BRAIN AND GASTROINTESTINAL TRACT OF C57BL/6 MICE: POTENTIAL PROTECTIVE ROLE OF N-ACETYLSEROTONIN [PDF]

Assiut Veterinary Medical Journal
The current study tried to explore the neuroprotective effects of N-Acetylserotonin (NAS) against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxopathological derangements in C57BL/6 mice.
ROFIDA TAGHYAN, MOKHTAR TAHA, XIAOJING, JIA, RAUSCH, WOLF-DIETER, RADAD, KHALED   +4 more
doaj   +1 more source

MPTP-induced loss of TH positive neurons in the substantia nigra pars compacta.

, 2016
(A-D) Representative images of dopaminergic neurons stained for tyrosine hydroxylase (TH) in coronal midbrain sections of ASIC1a+/+ and ASIC1a-/- mice 14 days after MPTP or saline treatment. The framed area of the lateral SNc represents the area analyzed
Arno Reich (163313), Silke Imgrund (3335688), Daniel Komnig (3335694), Stefan Gründer (652717), Björn H. Falkenburger (3335691)   +4 more
core   +1 more source

Efeitos do tratamento com agmatina sobre as alterações comportamentais e neuroquímicas verificadas em um modelo experimental da doença de Parkinson em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011A agmatina é uma substância endógena que possui características neuromoduladoras.
Matheus, Filipe Carvalho
core  

MgATPase Activity is Dispensable for the Pharmacological Regulation of the Functional Effects of the KATP Channels Opening in Brain Mitochondria

Frontiers in Bioscience-Landmark
Background: The mechanisms underlying the effects of pharmacological mitochondrial ATP-sensitive K+ channel (mKATP) channel openers on the functional effects of the mKATP channels opening remain disputable.
Olga V. Akopova, Anton Smirnov
doaj   +1 more source

Um modelo de amnésia associada à doença de Parkinson: estudos comportamentais e neuroquímicos em ratos lesados com 1-metil-4-fenil-1,2,3,6-tetrahidropiridina (MPTP) [PDF]

, 2001
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.A doença de Parkinson (DP) é um distúrbio neurodegenativo caracterizada pelo aparecimento de alterações motoras e ...
Gevaerd, Monique da Silva
core  

Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction [PDF]

, 2009
Mitochondrial dysfunction is thought to contribute to neurodegenerative processes. As an example, dysfunction of complex I of the electron transport chain has been observed in Parkinson’s disease patients and 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (
Burté, F, Burte, Florence
core  

KEGG pathway list of 12 proteins which were down-regulated in MPTP versus saline and up-regulated in MPTP+KRG versus MPTP.

, 2016
KEGG pathway list of 12 proteins which were down-regulated in MPTP versus saline and up-regulated in MPTP+KRG versus MPTP.
Ki-Tae Ha (564103), Dongsoo Kim (769465), Hyongjun Jeon (3279474), Seungtae Kim (3279471), Sun Ryu (511906), Sungtae Koo (3279477)   +5 more
core   +1 more source

Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease

Folia Histochemica et Cytobiologica, 2012
Docosahexaenoic acid (DHA), a major polyunsaturated fatty acid (PUFA) in the phospholipid fraction of the brain, is essential for normal cellular function. Neurodegenerative disorders such as Parkinson’s disease (PD) often exhibit significant declines in
Gulay Hacioglu, Yasemin Seval-Celik, Gamze Tanriover, Ozlem Ozsoy, Esen Saka-Topcuoglu, Sevin Balkan, Aysel Agar   +6 more
doaj   +1 more source

Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease

Journal of Integrative Neuroscience
Background: Mitochondrial dysfunction is one of the major hallmarks of Parkinson’s disease (PD). Recently, angiotensin II type 1 and type 2 receptors (AT1R, AT2R) were reported to be present on the mitochondrial membrane.
Bipul Ray, Sunanda Tuladhar, Pramod Gudigenahally Nagaraju, Ashwini Shivalinga, Arehally Marappa Mahalakshmi, Poornima Priyadarshini, Byoung-Joon Song, Saravana Babu Chidambaram   +7 more
doaj   +1 more source