Results 51 to 60 of about 1,557,014 (330)

Propylthiouracil-induced mitochondrial dysfunction in liver and its relevance to drug-induced hepatotoxicity

Pharmaceutical Sciences, 2017
Background: Propylthiouracil (PTU) administration is associated with several cases of hepatotoxicity, especially in children. The mechanism(s) of PTU-induced hepatotoxicity is obscure.
Akram Jamshidzadeh 1,2, Hossein Niknahad, Reza Heidari, Maryam Azadbakht, Forouzan Khodaei, Mohammad Reza Arabnezhad, Omid Farshad
doaj   +1 more source

Propofol-Induced Mitochondrial Dysfunction Is Independent of Mitochondrial Permeability Transition

Biomedicines
Background/Objectives: In recent years, it has been suggested that sedatives may cause brain damage. One possible mechanism is interference with oxidative phosphorylation of brain mitochondria, but much remains unknown.
Aya Kawachi, Shoichiro Shibata, Eskil Elmér, Hiroyuki Uchino   +3 more
doaj   +1 more source

Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains

International Journal of Cell Biology, 2014
We investigated whether genetic radiosensitivity-related changes in mtDNA/nDNA ratios are significant to mitochondrial function and if a material effect on mtDNA content and function exists.
Steven B. Zhang, David Maguire, Mei Zhang, Yeping Tian, Shanmin Yang, Amy Zhang, Katherine Casey-Sawicki, Deping Han, Jun Ma, Liangjie Yin, Yongson Guo, Xiaohui Wang, Chun Chen, Alexandra Litvinchuk, Zhenhuan Zhang, Steven Swarts, Sadasivan Vidyasagar, Lurong Zhang, Paul Okunieff   +18 more
doaj   +1 more source

Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice

Neural Regeneration Research, 2023
The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang, Kai-Yuan Zhang, Xue-Zhu Chen, Chuan-Yan Yang, Ju Wang, Xue-Jiao Lei, Yu-Lian Quan, Wei-Xiang Chen, Heng-Li Zhao, Li-Kun Yang, Yu-Hai Wang, Yu-Jie Chen, Hua Feng   +12 more
doaj   +1 more source

Experimental assessment of carbacetam effect on the cerebral mitochondria in rats with scopolamine-induced Alzheimer’s disease [PDF]

Archives of the Balkan Medical Union, 2020
Introduction. One of the pathogenic chains in neurodegenerative diseases, and the Alzheimer’s disease especially, is the disorder of cellular energy supply.
Olga G. KMET, Nataliia D. FILIPETS, Iryna M. YAREMII, Taras I. KMET, Yurii M. VEPRIUK, Tamara I. HRACHOVA   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tissue Specific Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ Ions

Acta Medica, 2009
Ca2+-induced opening of the mitochondrial permeability transition pore (MPTP) is involved in induction of apoptotic and necrotic processes. We studied sensitivity of MPTP to calcium using the model of Ca2+-induced, cyclosporine A-sensitive mitochondrial ...
René Endlicher, Pavla Křiváková, Halka Lotková, Marie Milerová, Zdeněk Drahota, Zuzana Červinková   +5 more
doaj   +1 more source

Quantitation of effects on mitochondrial swelling: some effects of ATP and aging

, 1962
A method has been devised for the quantitative measurement of relative effects of substances or conditions on rate of change of mitochondrial volume. It can be used to study the effects progressively as the mitochondria swell. By this means, the effects
Charles McGaughey
core   +1 more source

Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

BMC Microbiology, 2013
BackgroundNaphthoquinones (NQs) are privileged structures in medicinal chemistry due to the biological effects associated with the induction of oxidative stress.
K. Salomão, N. A. D. de Santana, M. Molina, S. D. de Castro, R. Menna-Barreto   +4 more
semanticscholar   +1 more source

The prevention of curcumin against rat liver mitochondrial swelling induced by tert-butylhydroperoxide [PDF]

, 2006
Liver diseases have been a medical problem which is difficult to manage. Some of the problems in the treatment of these diseases lie in the lack of reliable drug available.
Suyatna, Frans D., Susilowati, S., Setiawati, A.   +2 more
core   +1 more source