Results 181 to 190 of about 8,821,559 (269)

Mitochondrial unfolded protein response in regulatory T cell function: a protective mechanism in immune aging. [PDF]

Front Immunol
Lewis L, Valvi D, Gedaly R, Marti F.
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

The therapeutic effect of nicotinamide riboside chloride on ameliorating alcohol-induced neuronal damage with a focus on mitochondrial unfolded protein response and mitophagy. [PDF]

Genes Dis
Wang J, Wang J, Xie W, Shen Q, Wang C, Li R, Deng S.   +6 more
europepmc   +1 more source

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

Mitochondrial unfolded protein response (UPR^mt) as novel therapeutic targets for neurological disorders. [PDF]

J Cereb Blood Flow Metab
Chen X, An H, He J, Guo J, Xu S, Wu C, Wu D, Ji X.   +7 more
europepmc   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Involvement of mitochondrial unfolded protein response and activating transcription factor 4 in the mitochondrial damage pathway of BEAS-2B cells induced by cigarette smoke extracts. [PDF]

J Thorac Dis
Jin J, Cen T, Huang M, Xu F, Ding Q, Lv D, Wang S, Fei L, Ma H, Fu P.   +9 more
europepmc   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

BMAL1 modulation alleviates inflammatory responses in monocytes by targeting the Fis1-mediated mitochondrial unfolded protein response in high-altitude hypoxia. [PDF]

Cell Commun Signal
Ge YL, Xu J, Cai Y, Zhang B, He SY, Li PJ, Bu YR, Zhang L, Yu ZB, Ma H, Liu Y, Chen XW, Xie MJ.   +12 more
europepmc   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source