Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease
Glia, Volume 74, Issue 3, March 2026.APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar +8 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background and Aims The Charcot–Marie–Tooth disease (CMT) comprises genetically diverse motor and sensory neuropathies. This study aims to conduct a comprehensive investigation into the current academic and clinical status of CMT, thereby providing researchers with an extensive understanding of the research landscape and analysis of prevailing
Lanxiao Cao +4 more
wiley +1 more source
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities
MedComm, Volume 7, Issue 3, March 2026.Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou +5 more
wiley +1 more source
PINK1‐induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension [PDF]
, 2021 Asish Dasgupta +10 more
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Cell Proliferation, Volume 59, Issue 3, March 2026.Pioglitazone suppresses mitochondrial excessive ROS generation and COX‐2 level through inhibition of Drp‐1 mediated mitochondrial fission in an AMPK‐dependent manner in LS. ABSTRACT Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress ...
Jie Luo +5 more
wiley +1 more source
Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene ( PGC1A ) during weight loss is related to insulin sensitivity but not to energy expenditure [PDF]
, 2018 Aims/hypothesis: We investigated whether skeletal muscle peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1A; also known as PPARGC1A) and its target mitofusin-2 (MFN2), as well as carnitine palmitoyltransferase-1 (CPT1; also known as ...
Barthassat, V. +7 more
core
Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton [PDF]
, 2019 Wenqing Zhou +9 more
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The FEBS Journal, Volume 293, Issue 6, Page 1741-1753, March 2026.The bacterial dynamin‐like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane association is essential for its protective function, likely preventing explosive membrane rupture following phage infection.
Samia Shafqat +2 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 3, March 2026.Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus +2 more
wiley +1 more source
Mechanisms of disease and clinical features of mutations of the gene for mitofusin 2: an important cause of hereditary peripheral neuropathy with striking clinical variability in children and adults [PDF]
, 2010 Robert Ouvrier, S. Grew
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