Results 71 to 80 of about 16,238 (247)

Pathological classification of equine recurrent laryngeal neuropathy [PDF]

, 2018
Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left‐sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle ...
Draper, A C E, Piercy, R J
core   +2 more sources

Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction

Neural Regeneration Research
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen, Hao Tang, Mingfen Tian, Ling Wang, Qinghuan Yang, Yong Zhao, Xuemei Li, Yu Ren, Jiani Wang, Li Zhou, Yongjun Tan, Haiyun Wu, Xinrui Cai, Yilin Wang, Hui Cao, Jianfeng Xu, Qin Yang   +16 more
doaj   +1 more source

Mitofusin 2 Deficiency Affects Energy Metabolism and Mitochondrial Biogenesis in MEF Cells. [PDF]

PLoS ONE, 2015
Mitofusin 2 (Mfn2), mitochondrial outer membrane protein which is involved in rearrangement of these organelles, was first described in pathology of hypertension and diabetes, and more recently much attention is paid to its functions in Charcot-Marie ...
Maria Kawalec, Anna Boratyńska-Jasińska, Małgorzata Beręsewicz, Dorota Dymkowska, Krzysztof Zabłocki, Barbara Zabłocka   +5 more
doaj   +1 more source

Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]

, 2017
BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D, Edgar, Kevin S, Grieve, David J, Kearney, Anna M, McDermott, Barbara J, McLaughlin, Declan, O'Neill, Karla M, Zhao, Youyou   +7 more
core   +1 more source

Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages [PDF]

Cells, 2019
Apoptosis is an important host defense mechanism against mycobacterial infection. However, the molecular mechanisms regulating apoptosis during mycobacterial infection are not well known. Recent reports suggest that bacterial infection regulates mitochondrial fusion and fission in various ways.
Junghwan Lee, Ji-Ae Choi, Soo-Na Cho, Sang-Hun Son, Chang-Hwa Song   +4 more
openaire   +3 more sources

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations [PDF]

, 2016
Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not properly understood.
De Vos, K.J., Gomez‐Suaga, P., Gray, E.H., Hanger, D.P., Lau, D.H.W., Miller, C.C.J., Mitchell, J.C., Noble, W., Paillusson, S., Sancho, R.M., Shaw, C.E., Stoica, R., Vizcay‐Barrena, G.   +12 more
core   +4 more sources

Mitofusin-2 prevents skeletal muscle wasting in cancer cachexia

Oncology Letters, 2016
Cancer cachexia remains a leading cause of morbidity and mortality worldwide, despite extensive research and clinical trials. The prominent clinical feature of cancer cachexia is the continuous loss of skeletal muscle that cannot be fully reversed by conventional nutritional support, and that leads to progressive functional impairment.
Qiu-Lei, Xi, Bo, Zhang, Yi, Jiang, Hai-Sheng, Zhang, Qing-Yang, Meng, Ying, Chen, Yu-Song, Han, Qiu-Lin, Zhuang, Jun, Han, Hai-Yu, Wang, Jing, Fang, Guo-Hao, Wu   +11 more
openaire   +3 more sources

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential [PDF]

Nature, 2016
Haematopoietic stem cells (HSCs), which sustain production of all blood cell lineages, rely on glycolysis for ATP production, yet little attention has been paid to the role of mitochondria. Here we show in mice that the short isoform of a critical regulator of HSCs, Prdm16 (refs 4, 5), induces mitofusin 2 (Mfn2), a protein involved in mitochondrial ...
Luchsinger, Larry L, de Almeida, Mariana Justino, Corrigan, David J, Mumau, Melanie, Snoeck, Hans-Willem   +4 more
openaire   +2 more sources

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]

, 2018
Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva, Iozzo, Renato V., Mongiat, Maurizo, Neill, Thomas, Peiper, Stephen C., Wang, Zi-Xuan   +5 more
core   +1 more source