Results 11 to 20 of about 229,005 (218)

Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion. [PDF]

PLoS ONE, 2018
OBJECTIVES:To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of ...
Leticia Serrano-Oviedo, Marta Ortega-Muelas, Jesús García-Cano, María Ll Valero, Francisco J Cimas, Raquel Pascual-Serra, Diego M Fernandez-Aroca, Olga Roche, María J Ruiz-Hidalgo, Borja Belandia, José M Giménez-Bachs, Antonio S Salinas, Ricardo Sanchez-Prieto   +12 more
doaj   +1 more source

Genomic structure of carp mitogen-activated protein kinase kinase 1 gene [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996
Carp mitogen-activated protein kinase kinase 1 (cMKK1) gene was isolated from a liver genomic library. The sequence around the exon-intron boundaries and 2 kb of the promoter region were determined. Our data indicate that this gene is composed of 11 exons and 10 introns spanning about 9 kb. Multiple potential transcription initiation sites were located
J H, Leu, M S, Lee, K T, Chen, G D, Chang, C k, Chou, C J, Huang   +5 more
openaire   +2 more sources

Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways [PDF]

Journal of Biological Chemistry, 2013
Mitogen-activated protein kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial role in the deactivation of MAPKs. Several drugs with immune-suppressive properties modulate MKP-1 expression as part of their mechanism of action. We investigated the effect of mTOR inhibition through rapamycin and a dual mTOR
Ruchi, Rastogi, Zhongliang, Jiang, Nisar, Ahmad, Rita, Rosati, Yusen, Liu, Laurent, Beuret, Robert, Monks, Jean, Charron, Morris J, Birnbaum, Lobelia, Samavati   +9 more
openaire   +2 more sources

Regulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle [PDF]

American Journal of Physiology-Cell Physiology, 2016
Vascular smooth muscle contraction is primarily regulated by phosphorylation of myosin light chain. There are also modulatory pathways that control the final level of force development. We tested the hypothesis that protein kinase C (PKC) and mitogen-activated protein (MAP) kinase modulate vascular smooth muscle activity via effects on MAP kinase ...
Danielle M, Trappanese, Sarah, Sivilich, Hillevi K, Ets, Farah, Kako, Michael V, Autieri, Robert S, Moreland   +5 more
openaire   +2 more sources

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways

Journal of Ginseng Research, 2016
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin, Wei Yang, Dongxu Feng, Xinwen Wang, Muyao Qi, Tianxin Du, Hongzhi Sun, Shufang Wu   +7 more
doaj   +1 more source

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

ARABIDOPSIS ATMKK1 KNOCKOUT MUTANT FLOWERS UNDER SHORT DAY CONDITIONS [PDF]

Journal of Plant Development
There are a variety of conditions that regulate flowering time in Arabidopsis, but there are no reported instances mitogen-activated protein kinase pathways playing a decisive role in flowering time.
Chad CONROY, Khadijah M. NIZAM, Tim XING
doaj   +1 more source

Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase [PDF]

Journal of Biological Chemistry, 1996
Mitogen-activated protein (MAP) kinases are a multigene family activated by many extracellular stimuli. There are three groups of MAP kinases based on their dual phosphorylation motifs, TEY, TPY, and TGY, which are termed extracellular signal-regulated protein kinases (ERK1/2), c-Jun N-terminal kinases, and p38, respectively.
J, Abe, M, Kusuhara, R J, Ulevitch, B C, Berk, J D, Lee   +4 more
openaire   +2 more sources

The Role of Big Mitogen-Activated Protein Kinase 1 (BMK1) / Extracellular Signal-Regulated Kinase 5 (ERK5) in the Pathogenesis and Progression of Atherosclerosis

Journal of Pharmacological Sciences, 2012
Big mitogen-activated protein kinase 1 (BMK1), also known as extracellular signal-regulated kinase 5 (ERK5), is a newly identified member of the mitogen-activated protein (MAP) kinase family.
Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kosuke Nagayama, Satoyasu Ito, Yuichi Tsuji, Kentaro Ozawa   +6 more
doaj   +1 more source

MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins   +9 more
doaj   +1 more source