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Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation
Acta Crystallographica Section F Structural Biology Communications, 2021Eukaryotic protein kinases contain an Asp-Phe-Gly (DFG) motif, the conformation of which is involved in controlling the catalytic activity, at the N-terminus of the activation segment. The motif can be switched between active-state (DFG-in) and inactive-state (DFG-out) conformations: however, the mechanism of conformational change is poorly understood,
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