International Journal of Cancer, EarlyView.Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang +5 more
wiley +1 more source
S-nitrosylation of the scaffold protein STRAP enhances oxidative stress-induced apoptosis. [PDF]
J Biol ChemXu W, Chen D, Zhou HL.
europepmc +1 more source
International Journal of Cancer, EarlyView.What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar +16 more
wiley +1 more source
Statement of Retraction: Alkannin reverses lipopolysaccharides-induced inflammatory responses by suppressing mitogen-activated protein kinase and nuclear factor kappa-B signalling. [PDF]
Bioengineeredeuropepmc +1 more source
Multifocal Rosai Dorfman disease and simultaneous endometrioid ovarian cancer: a case report. [PDF]
J Med Case RepGraf N +3 more
europepmc +1 more source
Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis
International Journal of Cancer, EarlyView.In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente +12 more
wiley +1 more source
AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma. [PDF]
NeoplasiaPaudel R +5 more
europepmc +1 more source
iMetaMed, EarlyView.Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen +4 more
wiley +1 more source
Hematopoietic progenitor kinase 1 inhibitor BGB-15025 induces apoptosis in acute myeloid leukemia cells through the cell cycle pathway and mitogen-activated protein kinase/extracellular signal-regulated kinase pathway signaling axis. [PDF]
Anticancer DrugsYang S +9 more
europepmc +1 more source
iMeta, EarlyView.We utilized single‐cell RNA sequencing (scRNA‐seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation.
Liang Shao +12 more
wiley +1 more source