Results 231 to 240 of about 234,908 (267)

MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus

Lupus, 2012
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune disease in which various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and interferon (IFN) play crucial pathogenic roles. The production of these cytokines is responsible for the mitogen-activated protein kinases (MAPKs), which can ...
J, Yang, Y-W, Lu, M-M, Lu, R-X, Leng, H-F, Pan, D-Q, Ye   +5 more
openaire   +2 more sources

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

Science, 1993
The guanosine triphosphate (GTP)-binding protein Ras functions in regulating growth and differentiation; however, little is known about the protein interactions that bring about its biological activity. Wild-type Ras or mutant forms of Ras were covalently attached to an insoluble matrix and then used to examine the interaction of signaling proteins ...
Moodie, S.A., Willumsen, Berthe Marie, Weber, M. J., Wolfman, A.   +3 more
openaire   +2 more sources

Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium

Journal of Cardiac Failure, 2002
Mitogen-activated protein kinases (MAPKs), consisting of the ERK1/2, JNKs, and p38-kinase families, play a key role in the regulation of myocyte growth and apoptosis in vitro. The activity of MAPKs is regulated by dual-specificity MAPK phosphatases (MKPs). Because myocardial failure is associated with myocyte hypertrophy and apoptosis, MAPKs may play a
Catherine, Communal, Wilson S, Colucci, Andrea, Remondino, Douglas B, Sawyer, J David, Port, Scott E, Wichman, Michael R, Bristow, Krishna, Singh   +7 more
openaire   +2 more sources

Regulation of tristetraprolin expression by mitogen‐activated protein kinase phosphatase‐1

APMIS, 2012
Tristetraprolin (TTP) is an acute phase protein, and its expression is rapidly up‐regulated by inflammatory signals, such as lipopolysaccharide (LPS) and cytokines. TTP regulates gene expression by governing the mRNA stability of its target genes, which include cytokines and growth factors. MAP kinase phosphatase‐1 (MKP‐1) is a nuclear phosphatase that
Noora, Huotari, Tuija, Hömmö, Ville, Taimi, Riina, Nieminen, Eeva, Moilanen, Riku, Korhonen   +5 more
openaire   +2 more sources

Mitogen-activated protein kinase phosphatase-1 in olfactory neural regeneration

NeuroReport, 2000
Uniquely, olfactory neurons continuously replace themselves. Olfactory bulb ablation induces coordinated degeneration and regeneration in olfactory neuroepithelium; up-regulated growth factors bind to their receptors, initiating a phosphorylation cascade activating mitogen-activated protein kinases (MAPK).
M, Shinogami, T, Ishibashi
openaire   +2 more sources

Hypoxia and Hypoxia/Reoxygenation Activate Raf-1, Mitogen-Activated Protein Kinase Kinase, Mitogen-Activated Protein Kinases, and S6 Kinase in Cultured Rat Cardiac Myocytes

Circulation Research, 1996
Abstract In response to hypoxia and reoxygenation, mammalian cells are known to express a variety of genes to adapt to these external stresses or lead to further cell damage. We investigated the intracellular signaling cascades in cultured rat cardiac myocytes subjected to hypoxia or hypoxia followed by reoxygenation (hypoxia ...
Y, Seko, K, Tobe, K, Ueki, T, Kadowaki, Y, Yazaki   +4 more
openaire   +2 more sources

Interdependent Domains Controlling the Enzymatic Activity of Mitogen-Activated Protein Kinase Kinase 1

Biochemistry, 1996
The activation of human mitogen-activated protein kinase kinase 1 (MKK1) is achieved by phosphorylation at Ser218 and Ser222 within a regulatory loop. Partial activation was achieved by replacing these residues with aspartic/glutamic acid. Higher activity was obtained by introducing four acidic residue substitutions in the regulatory loop, indicating ...
S J, Mansour, J M, Candia, J E, Matsuura, M C, Manning, N G, Ahn   +4 more
openaire   +2 more sources

Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader

Journal of Medicinal Chemistry, 2019
MEK1 and MEK2 (also known as MAP2K1 and MAP2K2) are the "gatekeepers" of the ERK signaling output with redundant roles in controlling ERK activity. Numerous inhibitors targeting MEK1/2 have been developed including three FDA-approved drugs. However, acquired resistance to MEK1/2 inhibitors has been observed in patients, and new therapeutic strategies ...
Jieli Wei, Jianping Hu, Li Wang, Ling Xie, Margaret S. Jin, Xian Chen, Jing Liu, Jian Jin   +7 more
openaire   +2 more sources

Mitogen-activated Protein Kinase big Mitogen-activated Kinase-1 Mediates Protection in Liver Ischemia/Reperfusion Injury

Transplantation
Background. Hepatic ischemia/reperfusion injury (IRI) is a major complication occurring in hemorrhagic shock, liver resection, and transplantation. Big mitogen-activated kinase-1 (BMK1), a member of the mitogen-activated protein kinases family, is essential for regulating endothelial cell integrity and organ ...
Yuan Liu, Aiwei Zhou, Zhipeng Zong, Douglas G Farmer, Jerzy W. Kupiec-Weglinski, Qiang Xia, Haofeng Ji   +6 more
openaire   +1 more source

The Effects of IL-1 on Mitogen-Activated Protein Kinases in Rabbit Articular Chondrocytes

Biochemical and Biophysical Research Communications, 1997
IL-1-activated chondrocytes express a large number of genes which contribute to cartilage degradation. The signaling pathways activated in response to IL-1 in these cells are not well-defined. We examined the effects of IL-1 and other stimuli on the mitogen activated protein kinase (MAPK) pathways in rabbit articular chondrocytes.
P A, Scherle, M A, Pratta, W S, Feeser, E J, Tancula, E C, Arner   +4 more
openaire   +2 more sources