Results 281 to 290 of about 376,373 (310)

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1

Bioorganic & Medicinal Chemistry, 2006
Protein tyrosine phosphatases have a central role in the maintenance of normal cellular functionality. For example, PTP1B has been implicated in insulin-resistance, obesity, and neoplasia. Mitogen-activated protein kinase phosphatase-1 (MKP-1 or DUSP1) dephosphorylates and inactivates mitogen-activated protein kinase (MAPK) substrates, such as p38, JNK,
John S, Lazo, Ruth, Nunes, John J, Skoko, Pierre E, Queiroz de Oliveira, Andreas, Vogt, Peter, Wipf   +5 more
openaire   +2 more sources

Induction of Mitogen-Activated Protein Kinase Phosphatase-1 During Acute Hypertension

Hypertension, 1997
Abstract Recently, we demonstrated that elevated blood pressure activates mitogen-activated protein (MAP) kinases in rat aorta. Here we provide evidence that the vascular response to acute hypertension also includes induction of MAP kinase phosphatase-1 (MKP-1), which has been shown to function in the dephosphorylation and ...
Q, Xu, T W, Fawcett, M, Gorospe, K Z, Guyton, Y, Liu, N J, Holbrook   +5 more
openaire   +2 more sources

Angiopoietin‐1 activates both anti‐ and proapoptotic mitogen‐activated protein kinases

The FASEB Journal, 2003
ABSTRACT In this study, we identified whether mitogen‐activated protein kinases (MAPKs) mediate the effects of angiopoietin‐1 (Ang‐1) on endothelial cell apoptosis. Exposure of human umbilical vein endothelial cells to Ang‐1 (300 ng/ml) evoked within 15–30 min a 15‐fold and a 5‐fold increase in phosphorylation of ERK1/2 and p38 MAPKs,
Rania, Harfouche, Jean-Philippe, Gratton, George D, Yancopoulos, Michela, Noseda, Aly, Karsan, Sabah N A, Hussain   +5 more
openaire   +2 more sources

Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader

Journal of Medicinal Chemistry, 2019
MEK1 and MEK2 (also known as MAP2K1 and MAP2K2) are the "gatekeepers" of the ERK signaling output with redundant roles in controlling ERK activity. Numerous inhibitors targeting MEK1/2 have been developed including three FDA-approved drugs. However, acquired resistance to MEK1/2 inhibitors has been observed in patients, and new therapeutic strategies ...
Jieli Wei, Jianping Hu, Li Wang, Ling Xie, Margaret S. Jin, Xian Chen, Jing Liu, Jian Jin   +7 more
openaire   +2 more sources

Mitogen-Activated Protein Kinase Kinase Kinase 1

2020
openaire   +1 more source

MORG1 (Mitogen-Activated Protein Kinase Organizer 1)

2016
Ivonne Loeffler, Gunter Wolf
openaire   +1 more source

Mitogen‐activated protein kinase cascades in plant signaling

Journal of Integrative Plant Biology, 2022
Mengmeng Zhang, Shuqun Zhang
exaly  

AMP-activated protein kinase: the current landscape for drug development

Nature Reviews Drug Discovery, 2019
Gregory R Steinberg, David Carling
exaly  

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1

2018
openaire   +1 more source

Targeting proteinase-activated receptors: therapeutic potential and challenges

Nature Reviews Drug Discovery, 2012
Rithwik Ramachandran, Farshid Noorbakhsh, Kathryn DeFea   +2 more
exaly