Dual specificity phosphatase 1 attenuates inflammation-induced cardiomyopathy by improving mitophagy and mitochondrial metabolism [PDF]
Molecular Metabolism, 2022 Objectives: Dual specificity phosphatase 1 (DUSP1) is regarded as an anti-inflammatory factor in cardiovascular disorders. Mitophagy removes damaged mitochondria and thus promotes mitochondrial regeneration.
Ying Tan +10 more
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Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory Responses [PDF]
Frontiers in Immunology, 2019 Glucocorticoids (GCs) potently inhibit pro-inflammatory responses and are widely used for the treatment of inflammatory diseases, such as allergies, autoimmune disorders, and asthma. Dual-specificity phosphatase 1 (DUSP1), also known as mitogen-activated
Jessica Hoppstädter +2 more
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Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis. [PDF]
PLoS ONE, 2015 BackgroundOsteoarthritis (OA) is a degenerative joint disease with poorly understood etiology and pathobiology. Mitogen activated protein kinases (MAPKs) including ERK and p38 play important roles in the mediation of downstream pathways involved in ...
Michael Andrew Pest +4 more
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Dual specificity phosphatase 1 as a non-invasive circulating biomarker candidate in preeclampsia [PDF]
Frontiers in EndocrinologyIntroductionPreeclampsia (PE) is a multisystem pregnancy complication. Factors pointing to a placental origin are the development of the pathology only during pregnancy, and its disappearance in the post-partum period.MethodsHere, we aim to identify ...
Jonatane Andrieu +12 more
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Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea [PDF]
Antioxidants, 2021 Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activation.
Jose M. Bermúdez-Muñoz +6 more
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Crystal structure of the human dual specificity phosphatase 1 catalytic domain. [PDF]
Protein Sci, 2018 AbstractThe dual specificity phosphatase DUSP1 was the first mitogen activated protein kinase phosphatase (MKP) to be identified. It dephosphorylates conserved tyrosine and threonine residues in the activation loops of mitogen activated protein kinases ERK2, JNK1 and p38‐alpha.
Gumpena R +5 more
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Expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) in tumor cells. [PDF]
PLoS ONE, 2014 Sequencing of individual clones from a newly established cDNA library from the chemoresistant Hodgkin's lymphoma cell line L-1236 led to the isolation of a cDNA clone corresponding to a short sequence from chromosome 1.
Martin S Staege +6 more
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Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids. [PDF]
PLoS ONE, 2010 BackgroundGlucocorticoids are potent anti-inflammatory agents commonly used to treat inflammatory diseases. They convey signals through the intracellular glucocorticoid receptor (GR), which upon binding to ligands, associates with genomic glucocorticoid ...
Lauren E Shipp +6 more
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Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide. [PDF]
J Immunol, 2015 Abstract Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide variety of experimental ...
Smallie T +10 more
europepmc +5 more sources
Role of dual specificity phosphatase 1 in influencing inflammatory pathways in macrophages modulated by Borrelia burgdorferi lipoproteins [PDF]
Frontiers in ImmunologyBorrelia burgdorferi (Bb), the spirochetal agent of Lyme disease, has a large array of lipoproteins that play a significant role in mediating host-pathogen interactions within ticks and vertebrates.
Venkatesh Kumaresan +5 more
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