Results 21 to 30 of about 133,554 (285)

Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex [PDF]

, 2012
The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST).
Danko Georgiev, David A. Lewis, Guillermo González-Burgos, Mitsuru Kikuchi, Takanori Hashimoto, Takeo Yoshikawa, Yoshio Minabe   +6 more
core   +23 more sources

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells

Frontiers in Cell and Developmental Biology, 2022
P2X7 receptor (P2RX7) is expressed strongly by most human cancers, including neuroblastoma, where high levels of P2RX7 are correlated with a poor prognosis for patients.
María Benito-León, María Benito-León, María Benito-León, Juan Carlos Gil-Redondo, Juan Carlos Gil-Redondo, Juan Carlos Gil-Redondo, Juan Carlos Gil-Redondo, Raquel Perez-Sen, Raquel Perez-Sen, Raquel Perez-Sen, Esmerilda G. Delicado, Esmerilda G. Delicado, Esmerilda G. Delicado, Felipe Ortega, Felipe Ortega, Felipe Ortega, Rosa Gomez-Villafuertes, Rosa Gomez-Villafuertes, Rosa Gomez-Villafuertes   +18 more
doaj   +1 more source

Mitogen-Activated Protein Kinase Phosphatase 1/Dual Specificity Phosphatase 1 Mediates Glucocorticoid Inhibition of Osteoblast Proliferation [PDF]

Molecular Endocrinology, 2007
Steroid-induced osteoporosis is a common side effect of long-term treatment with glucocorticoid (GC) drugs. GCs have multiple systemic effects that may influence bone metabolism but also directly affect osteoblasts by decreasing proliferation. This may be beneficial at low concentrations, enhancing differentiation. However, high-dose treatment produces
Horsch, K., Wet, H. de, Schuurmans, M. M., Allie-Reid, F., Cato, A. C. B., Cunningham, J., Burrin, J. M., Hough, F. S., Hulley, P. A.   +8 more
openaire   +3 more sources

N6-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections

mBio, 2023
Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections.
Jian Feng, Wen Meng, Luping Chen, Xinquan Zhang, Ashley Markazi, Weiming Yuan, Yufei Huang, Shou-Jiang Gao   +7 more
doaj   +1 more source

Genkwanin suppresses mitochondrial dysfunction to alleviate IL-1β-elicited inflammation, apoptosis, and degradation of extracellular matrix in chondrocytes through upregulating DUSP1

Chinese Journal of Physiology, 2023
Osteoarthritis (OA) is a form of chronic degenerative disease contributing to elevated disability rate among the elderly. Genkwanin is an active component extracted from Daphne genkwa possessing pharmacologic effects.
Kanna Xu, Haoran Wang, Zhongqing Wu
doaj   +1 more source

Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology [PDF]

, 2016
Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of
Celada Cotarelo, Antonio, Lloberas Cavero, Jorge, Tur Torres, Juan, Valverde Estrella, Lorena, Vico Rivero, Tania   +4 more
core   +1 more source

DUSP1 (dual specificity phosphatase 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on DUSP1 (dual specificity phosphatase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1 [PDF]

Proceedings of the National Academy of Sciences, 2001
The mitogen-activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli, such as growth factors, hormones, and cytokines, and to a wide variety of environmental stresses. The MAPKs, which are stimulated by phosphorylation of a TXY motif in their activation loop, are components of signal transduction ...
Y, Shen, R, Luche, B, Wei, M L, Gordon, C D, Diltz, N K, Tonks   +5 more
openaire   +2 more sources

Protein Expression, Characterization and Activity Comparisons of Wild Type and Mutant DUSP5 Proteins [PDF]

, 2014
Background The mitogen-activated protein kinases (MAPKs) pathway is critical for cellular signaling, and proteins such as phosphatases that regulate this pathway are important for normal tissue development.
Gastonguay, Adam J., Jensen, David R., Kalous, Kelsey S, Kutty, Raman G., Nayak, Jaladhi, Pokkuluri, Phani Raj, Ramchandran, Ramani, Rathore, Rajendra, Sem, Daniel S., Span, Elise A., Talipov, Marat R., Vakeel, Padmanabhan   +11 more
core   +2 more sources

Control of dual‐specificity phosphatase‐1 expression in activated macrophages by IL‐10 [PDF]

European Journal of Immunology, 2005
AbstractLigation of Toll‐like receptors (TLR) on macrophages induces cytokines and mediators important for the control of pathogens. Macrophage activation has to be tightly controlled to prevent hyper‐inflammation. Accordingly, the hallmarks of TLR‐triggered signaling, nuclear translocation of NF‐κB and phosphorylation of mitogen‐activated protein ...
Michael, Hammer, Jörg, Mages, Harald, Dietrich, Frank, Schmitz, Frank, Striebel, Peter J, Murray, Hermann, Wagner, Roland, Lang   +7 more
openaire   +2 more sources