Results 11 to 20 of about 133,554 (285)

Obstructive sleep apnea and intermittent hypoxia increase expression of dual specificity phosphatase 1. [PDF]

Atherosclerosis, 2013
Dual specificity phosphatase 1 (DUSP1) inhibits mitogen activated protein kinase activity, and is activated by several stimuli such as sustained hypoxia, oxidative stress, and hormones. However, the effect of intermittent hypoxia is not known. The aim of this study was to evaluate the role of intermittent hypoxia on DUSP1 expression, and to validate ...
Hoffmann MS, Singh P, Wolk R, Narkiewicz K, Somers VK.   +4 more
europepmc   +4 more sources

Dual Specificity Phosphatase 1 Regulates Human Inducible Nitric Oxide Synthase Expression by p38 MAP Kinase [PDF]

Mediators of Inflammation, 2011
The role of dual specificity phosphatase 1 (DUSP1) in inducible nitric oxide synthase (iNOS) expression in A549 human pulmonary epithelial cells, J774 mouse macrophages and primary mouse bone marrow-derived macrophages (BMMs) was investigated.
Tuija Turpeinen, Riina Nieminen, Ville Taimi, Taina Heittola, Outi Sareila, Andrew R. Clark, Eeva Moilanen, Riku Korhonen   +7 more
doaj   +4 more sources

Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway [PDF]

Chinese Medical Journal, 2016
Background: Previously, we reported that dual-specificity phosphatase 1 (DUSP1) was differentially expressed in endometrioid adenocarcinoma (EEA). However, the role of DUSP1 in EEA progression and the relationship between DUSP1 and medroxyprogesterone ...
Yuan Yang, Jing-Yi Zhou, Li-Jun Zhao, Bao-Rong Gao, Xiao-Ping Wan, Jian-Liu Wang   +5 more
doaj   +2 more sources

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin [PDF]

Scientific Reports, 2017
In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecules, including ...
Tina Tang, Thomas E. Scambler, Tim Smallie, Helen E. Cunliffe, Ewan A. Ross, Dalya R. Rosner, John D. O’Neil, Andrew R. Clark   +7 more
doaj   +2 more sources

Exosome–transmitted microRNA‐133b inhibited bladder cancer proliferation by upregulating dual‐specificity protein phosphatase 1 [PDF]

Cancer Medicine, 2020
Bladder Cancer (BC) is the ninth most common tumor in the world and one of the most common malignant tumors of the urinary system. Some studies reported that miR‐133b expression is reduced in BC, but whether it plays a role in the development of BC and ...
Xiaoxiao Cai, Lili Qu, Jian Yang, Junwen Xu, Li Sun, Xiaowei Wei, Xiaojun Qu, Tingting Bai, Zhirui Guo, Yefei Zhu   +9 more
doaj   +3 more sources

Downregulated Dual-Specificity Protein Phosphatase 1 in Ovarian Carcinoma: A Comprehensive Study With Multiple Methods

Pathology and Oncology Research, 2022
Introduction: We aimed to explore the abnormal expression of dual-specificity protein phosphatase 1 (DUSP1) and its latent molecular mechanisms in ovarian carcinoma (OVCA).Materials and Methods: Two clinical cohorts collected from two different hospitals
Zi-Qian Liang, Rong-Quan He, Jia-Yuan Luo, Zhi-Guang Huang, Jie Li, Lu-Yang Zhong, Jun-Hong Chen, Su-Ning Huang, Lin Shi, Kang-Lai Wei, Jiang-Hui Zeng, Jing-Jing Zeng, Gang Chen   +12 more
doaj   +3 more sources

Gefitinib enhances sensitivity of endometrial cancer cells to progestin therapy via dual-specificity phosphatase 1. [PDF]

Oncotarget, 2017
In this study, we investigated if Gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, augments endometrial cancer (EC) therapy with medroxyprogesterone acetate (MPA). Combined treatment with Gefitinib plus MPA decreased the proliferation and invasiveness of the Ishikawa and RL952 EC cell lines more effectively than MPA treatment alone ...
Yang Y, Zhou J, Li X, Zhao L, Cheng Y, Lin Y, Wang J, Wei L, Dong Y, Wang J.   +9 more
europepmc   +3 more sources

Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer

Cancer Biology & Medicine, 2018
Mitogen-activated protein kinases (MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions.
Muhammad Khairi Ahmad, Nur Ainina Abdollah, Nurul Husna Shafie, Narazah Mohd Yusof, Siti Razila Abdul Razak   +4 more
doaj   +3 more sources

Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients. [PDF]

J Allergy Clin Immunol, 2010
Inhaled corticosteroids (ICSs) are considered first-line treatment for persistent asthma, yet there is significant variability in treatment response. Dual-specificity phosphatase 1 (DUSP1) appears to mediate the anti-inflammatory action of corticosteroids.We sought to determine whether variants in the DUSP1 gene are associated with clinical response to
Jin Y, Hu D, Peterson EL, Eng C, Levin AM, Wells K, Beckman K, Kumar R, Seibold MA, Karungi G, Zoratti A, Gaggin J, Campbell J, Galanter J, Chapela R, Rodríguez-Santana JR, Watson HG, Meade K, Lenoir M, Rodríguez-Cintrón W, Avila PC, Lanfear DE, Burchard EG, Williams LK.   +23 more
europepmc   +4 more sources

Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1.

Am J Physiol Heart Circ Physiol, 2012
Chronic hypertension induces cardiac remodeling, including left ventricular hypertrophy and fibrosis, through a combination of both hemodynamic and humoral factors. In previous studies, we showed that the heptapeptide ANG-(1–7) prevented mitogen-stimulated growth of cardiac myocytes in vitro, through a reduction in the activity of the MAPKs ERK1 and ...
McCollum LT, Gallagher PE, Ann Tallant E.   +2 more
europepmc   +4 more sources