Results 41 to 50 of about 229,005 (218)

Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger

Journal of Pharmacological Sciences, 2010
The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a ...
Tsunaki Higa, Takahiro Horinouchi, Hiroyuki Aoyagi, Hiroshi Asano, Tadashi Nishiya, Arata Nishimoto, Ikunobu Muramatsu, Soichi Miwa   +7 more
doaj   +1 more source

The regulation of AP-1 activity by mitogen-activated protein kinases [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs).
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Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase‐1 in microglial cells [PDF]

Journal of Applied Toxicology, 2010
AbstractMultiple studies demonstrate that manganese (Mn) exposure potentiates inflammatory mediator output from activated glia; this increased output is associated with enhanced mitogen activated protein kinase (MAPK: p38, ERK and JNK) activity. We hypothesized that Mn activates MAPK by activating the kinases upstream of MAPK, i.e. MKK‐3/6, MKK‐1/2 and
Patrick L, Crittenden, Nikolay M, Filipov   +1 more
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Mitogen-activated Protein Kinase Phosphorylates and Regulates the HIV-1 Vif Protein [PDF]

Journal of Biological Chemistry, 1998
The human immunodeficiency virus type 1 (HIV-1) Vif protein plays a critical role in virus replication and infectivity. Here we show that Vif is phosphorylated and regulated by p44/42 mitogen-activated protein kinase (MAPK). Vif phosphorylation by MAPK was demonstrated in vitro as well as in vivo and was shown to occur on serine and threonine residues.
X, Yang, D, Gabuzda
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Mitogen-Activated Protein Kinase Kinase Kinase 1 Overexpression Disrupts Development of the Ocular Surface Epithelium

Cells
Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) is a key signaling molecule essential for eyelid closure during embryogenesis. In mice, Map3k1 knockout leads to a fully penetrant eye-open at birth (EOB) phenotype due to disrupted MAPK signaling,
Maureen Mongan, Bo Xiao, Antonius Christianto, Yueh-Chiang Hu, Ying Xia   +4 more
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Endothelin-1 Induces Contraction via a Syk-Mediated p38 Mitogen-Activated Protein Kinase Pathway in Rat Aortic Smooth Muscle

Journal of Pharmacological Sciences, 2007
Although spleen tyrosine kinase (Syk) has crucial roles in various cells, its function on vascular smooth muscle contraction has not been determined. In the present study, we performed experiments to determine if Syk contributes to the endothelin-1 (ET-1)
Hwan Myung Lee, Kyung-Jong Won, Junghwan Kim, Hyo-Jun Park, Hyo Jin Kim, Hui Yul Roh, So Hee Lee, Chang-Kwon Lee, Bokyung Kim   +8 more
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Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, 2021
Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan, Jing Wang, Jin-feng Xu, Fei Tang, Lu Chen, Yu-zhu Tan, Chao-long Rao, Hui Ao, Cheng Peng   +8 more
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Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

Journal of Biological Chemistry, 1993
The c-raf-1 protooncogene encodes a Ser/Thr protein kinase. A mitogen-activated protein kinase-kinase (MAPKK) purified from bovine brain is phosphorylated and activated 4-9-fold in vitro by c-Raf-1 from mitogen-treated cells. c-Raf-1 protein kinase activity, measured by the phosphorylation of brain MAPKK substrate, is detectably activated within 1 min ...
J M, Kyriakis, T L, Force, U R, Rapp, J V, Bonventre, J, Avruch   +4 more
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Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases [PDF]

Oncogene, 2014
Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability and metabolism. Although these NAD(+)-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated signaling targets remain under-studied.
Yeung, Fan, Ramsey, Catherine S., Popko-Scibor, Anita E., Allison, David F., Gray, Lisa G., Shin, Min, Kumar, Manish, Li, Duo, McCubrey, James A., Mayo, Marty W.   +9 more
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Pervanadate inhibits mitogen‐activated protein kinase kinase‐1 in a p38^MAPK‐dependent manner [PDF]

FEBS Letters, 1998
In baboon smooth muscle cells (SMCs), pervanadate has a biphasic dose‐dependent effect on MEK‐1 activity. After a 30 min incubation period, low concentrations (1–10 μM) activate, while higher doses (30–100 μM) fail to stimulate MEK‐1. One possibility is that higher doses of pervanadate induce an additional signaling pathway that inhibits MEK‐1.
Daum, Günter, Kalmes, Andreas, Levkau, Bodo, Wang, Yunxia, Davies, Mark G, Clowes, Alexander W   +5 more
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