Results 1 to 10 of about 226,851 (168)

Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice [PDF]

Frontiers in Cellular Neuroscience, 2017
Mitogen-activated Protein Kinase Phosphatase 3 (MKP-3) has been involved in the negative regulation of insulin signaling. The absence of MKP-3 is also associated with reduced adiposity, increased energy expenditure and improved insulin sensitivity.
Bárbara de A. Rodrigues, Vitor R. Muñoz, Gabriel K. Kuga, Gabriel K. Kuga, Rafael C. Gaspar, Susana C. B. R. Nakandakari, Barbara M. Crisol, José D. Botezelli, Luciana S. S. Pauli, Adelino S. R. da Silva, Leandro P. de Moura, Leandro P. de Moura, Leandro P. de Moura, Dennys E. Cintra, Dennys E. Cintra, Eduardo R. Ropelle, Eduardo R. Ropelle, Eduardo R. Ropelle, José R. Pauli, José R. Pauli, José R. Pauli   +20 more
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Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice

Journal of Pain Research, 2017
Sladjana Skopelja-Gardner,1,* Madhurima Saha,1,* Perla Abigail Alvarado-Vazquez,2 Brenna S Liponis,1 Elena Martinez,1 E Alfonso Romero-Sandoval2 1Department of Anesthesiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Department of ...
Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA   +5 more
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Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
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Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage

Virulence, 2021
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao, Zheng Chen   +5 more
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Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion. [PDF]

PLoS ONE, 2018
OBJECTIVES:To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of ...
Leticia Serrano-Oviedo, Marta Ortega-Muelas, Jesús García-Cano, María Ll Valero, Francisco J Cimas, Raquel Pascual-Serra, Diego M Fernandez-Aroca, Olga Roche, María J Ruiz-Hidalgo, Borja Belandia, José M Giménez-Bachs, Antonio S Salinas, Ricardo Sanchez-Prieto   +12 more
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Changes of Signaling Pathways in Hypothalamic Neurons with Aging

Current Issues in Molecular Biology, 2023
The hypothalamus is an important regulator of autonomic and endocrine functions also involved in aging regulation. The aging process in the hypothalamus is accompanied by disturbed intracellular signaling including insulin/insulin-like growth factor-1 ...
Petr M. Masliukov
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Olea europaea Suppresses Inflammation by Targeting TAK1-Mediated MAP Kinase Activation

Molecules, 2021
Possessing a variety of medicinal functions, Olea europaea L. is widely cultivated across the world. However, the anti-inflammatory mechanism of Olea europaea is not yet fully elucidated.
Chaoran Song, Mi-Yeon Kim, Jae Youl Cho
doaj   +1 more source

A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia

Autophagy Reports, 2023
BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He, Jian Li, Yan Cao, Hai-Tao Wu, Li-Ying Wu   +4 more
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Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine Threonine Kinase 3/Mixed Lineage Kinase Domain-Like and Mitogen-Activated Protein Kinase Signaling

Frontiers in Physiology, 2021
Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li, Jing Zhang, Jing Zhang, Peng-Jie Wang, Peng-Jie Wang, Zi-Wei Zhang, Zi-Wei Zhang, Jia-Qiang Huang, Jia-Qiang Huang   +8 more
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Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model

European Journal of Histochemistry, 2022
Cisplatin (CDDP) has been widely used in cancer therapy, but it has been linked to side effects such as nephrotoxicity. Crocin is a carotenoid found in crocus and gardenia flowers that has been shown to have anti-oxidant properties, inhibit tumor growth,
Qichao Yin, Hua Xiong
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