Results 281 to 290 of about 227,000 (310)

Phosphatidylinositol 3-Kinase Stimulates Muscle Differentiation by Activating p38 Mitogen-Activated Protein Kinase

Biochemical and Biophysical Research Communications, 2000
The activation of both phosphatidylinositol 3-kinase (PI3-kinase) and p38 mitogen-activated protein kinase (p38 MAPK) is required for muscle differentiation. However, it is not known whether the signals from these two kinases interact during this process. In this work, we have investigated this using H9c2 cardiac myoblasts.
Y K, Chun, J, Kim, S, Kwon, S H, Choi, F, Hong, K, Moon, J M, Kim, S L, Choi, B S, Kim, J, Ha, S S, Kim   +10 more
openaire   +2 more sources

Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia–reperfusion injury in a nuclear factor-κB-independent manner

European Journal of Pharmacology, 2009
Nuclear factor kappa-B (NF-kappaB), mitogen-activated protein kinase3/MAPK1 and MAPK8 are involved in testicular ischemia reperfusion injury (testicular-I/R). NF-kappaB knock-out mice (KO) subjected to testicular-I/R have a reduced testicular damage, blunted MAPK8 activation and enhanced MAPK3/MAPK1 activity.
MINUTOLI, Letteria, ANTONUCCIO, Pietro, POLITO, FRANCESCA, BITTO, ALESSANDRA, SQUADRITO, Francesco, DI STEFANO V, NICOTINA, Piero Antonio, FAZZARI C, MAISANO D, ROMEO, Carmelo, ALTAVILLA, Domenica   +10 more
openaire   +3 more sources

The protein stannin binds 14-3-3ζ and modulates mitogen-activated protein kinase signaling

Molecular Brain Research, 2005
The molecular mechanisms underlying the selective toxicity of trimethyltin (TMT) remain unclear. Stannin (Snn), a protein preferentially expressed in TMT-sensitive cells, provides a direct link to the molecular basis for TMT toxicity. Recent evidence demonstrated that Snn peptides bind and de-alkylate TMT to dimethyltin (DMT); Snn may mediate both TMT ...
Collin E, Davidson, Brian E, Reese, Melvin L, Billingsley, Jong K, Yun   +3 more
openaire   +2 more sources

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

Science, 1998
MAP kinase phosphatase–3 (MKP-3) dephosphorylates phosphotyrosine and phosphothreonine and inactivates selectively ERK family mitogen-activated protein (MAP) kinases. MKP-3 was activated by direct binding to purified ERK2. Activation was independent of protein kinase activity and required binding of ERK2 to the noncatalytic amino-terminus of MKP-3 ...
M, Camps, A, Nichols, C, Gillieron, B, Antonsson, M, Muda, C, Chabert, U, Boschert, S, Arkinstall   +7 more
openaire   +2 more sources

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
John M Jumper, Richard Evans, Alexander Pritzel   +2 more
exaly  

Accurate prediction of protein structures and interactions using a three-track neural network

Science, 2021
Minkyung Baek, Frank DiMaio, Ivan Anishchenko   +2 more
exaly  

Highly accurate protein structure prediction for the human proteome

Nature, 2021
Kathryn Tunyasuvunakool, Jonas Adler, Zachary Wu   +2 more
exaly  

PROTAC targeted protein degraders: the past is prologue

Nature Reviews Drug Discovery, 2022
Miklos Bekes, David R Langley, Craig M Crews   +2 more
exaly  

Treatment of renal cell carcinoma: Current status and future directions

Ca-A Cancer Journal for Clinicians, 2017
Pedro Coelho Barata, Brian I Rini
exaly