Results 21 to 30 of about 227,000 (310)

Role of RAS signaling in ovarian cancer [version 1; peer review: 2 approved]

F1000Research, 2022
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning ...
Hesham M. Korashy, Shahab Uddin, Abdullah Azmi, Ajaz Bhat, Lubna Therachiyil, Anjana Anand   +5 more
doaj   +1 more source

Evidence for a Role of Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase in the Development of Testicular Ischemia-Reperfusion Injury [PDF]

Biology of Reproduction, 2005
Mitogen-activated protein kinase (MAPK) 3/MAPK1 (also known as ERK1/ERK2) plays an important role in the signal transduction pathways. To our knowledge, however, its role in the development of testicular ischemia-reperfusion injury has not yet been investigated.
MINUTOLI, Letteria, ANTONUCCIO, Pietro, ROMEO, Carmelo, NICOTINA, Piero Antonio, BITTO, ALESSANDRA, ARENA, SALVATORE, POLITO, FRANCESCA, ALTAVILLA, Domenica, TURIACO N, CUTRUPI A, ZUCCARELLO, Biagio, SQUADRITO, Francesco   +11 more
openaire   +3 more sources

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3 [PDF]

Journal of Biological Chemistry, 1996
Mitogen-activated protein/ERK kinase kinases (MEKKs) phosphorylate and activate protein kinases which in turn phosphorylate and activate the p42/44 mitogen-activated protein kinase (MAPK), c-Jun/stress-activated protein kinases (JNKs), and p38/Hog1 kinase. We have isolated the cDNAs for two novel mammalian MEKKs (MEKK 2 and 3).
Jonathan L. Blank, Pär Gerwins, Elicia M. Elliott, Susan Sather, Gary L. Johnson   +4 more
openaire   +2 more sources

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, 2021
Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan, Jing Wang, Jin-feng Xu, Fei Tang, Lu Chen, Yu-zhu Tan, Chao-long Rao, Hui Ao, Cheng Peng   +8 more
doaj   +1 more source

Control of host cell phosphorylation by Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2011
Phosphorylation is one of the most frequent modifications in intracellular signaling and is implicated in many processes ranging from transcriptional control to signal transduction in innate immunity.
Eva eHaenssler, Eva eHaenssler, Ralph R. Isberg, Ralph R. Isberg   +3 more
doaj   +1 more source

Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2 [PDF]

Journal of Biological Chemistry, 1999
The mitogen-activated protein kinase phosphatase 3 (MKP3)-catalyzed hydrolysis of aryl phosphates in the absence and presence of extracellular signal-regulated kinase 2 (ERK2) was investigated in order to provide insights into the molecular basis of the ERK2-induced MKP3 activation.
B, Zhou, Z Y, Zhang
openaire   +2 more sources

Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells

Journal of Pharmacological Sciences, 2009
.: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations ...
Sung Lyea Park, You-Mie Kim, Jin-Hee Ahn, Soo Hwan Lee, Eun Joo Baik, Chang-Hyun Moon, Yi-Sook Jung   +6 more
doaj   +1 more source

Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats

Anais da Academia Brasileira de Ciências, 2015
The phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways mediate β cell growth, proliferation, survival and death. We investigated whether protein restriction during pregnancy alters islet morphometry or the expression and ...
CRISTIANA S.B. SALVATIERRA, SÍLVIA R.L. REIS, ANA F.M. PESSOA, LETÍCIA M.I. DE SOUZA, LUIZ F. STOPPIGLIA, ROBERTO V. VELOSO, MARISE A.B. REIS, EVERARDO M. CARNEIRO, ANTONIO C. BOSCHERO, EDSON M. COLODEL, VANESSA C. ARANTES, MÁRCIA Q. LATORRACA   +11 more
doaj   +1 more source

Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools

Frontiers in Pharmacology, 2022
Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects
Yong Jiang, Yi-Zi Xie, Yi-Zi Xie, Chen-Wen Peng, Chen-Wen Peng, Kai-Nan Yao, Xue-Ying Lin, Xue-Ying Lin, Shao-Feng Zhan, Hong-Fa Zhuang, Hui-Ting Huang, Xiao-Hong Liu, Xiu-Fang Huang, Xiu-Fang Huang, Hang Li   +14 more
doaj   +1 more source

Modulation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 by Hepatitis C Virus Core Protein [PDF]

Journal of Virology, 2013
ABSTRACT Hepatitis C virus (HCV) is highly dependent on cellular proteins for its own propagation. In order to identify the cellular factors involved in HCV propagation, we performed protein microarray assays using the HCV core protein as a probe.
Huong T T, Ngo, Long V, Pham, Jong-Wook, Kim, Yun-Sook, Lim, Soon B, Hwang   +4 more
openaire   +2 more sources