Results 31 to 40 of about 227,000 (310)

The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis

Frontiers in Plant Science, 2015
In Arabidopsis three basic region leucine zipper (bZIP) transcription factor genes, bZIP17, bZIP28 and bZIP60, play crucial roles in the unfolded protein response (UPR). Previously we found that bZIP60 is one of the spermine-induces genes.
G.H.M. eSagor, Pratima eChawla, Dong Wook eKim, Thomas eBerberich, Seiji eKojima, Masaru eNiitsu, Tomonobu eKusano   +6 more
doaj   +1 more source

Inhibition of Mitogen-activated Protein Kinase Phosphatase 3 Activity by Interdomain Binding [PDF]

Journal of Biological Chemistry, 2008
Mitogen-activated protein (MAP) kinase phosphatase 3 (MKP3) is a cytoplasmic dual specificity phosphatase that functions to attenuate signaling via dephosphorylation and subsequent deactivation of its substrate and allosteric regulator, extracellular signal-regulated protein kinase 2 (ERK2).
John K, Mark, Rémy A, Aubin, Sophie, Smith, Mary Alice, Hefford   +3 more
openaire   +2 more sources

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function [PDF]

Journal of Biological Chemistry, 2010
Mitogen-activated protein kinase kinase 3 (MAP2K3) is a member of the dual specificity kinase group. Growing evidence links MAP2K3 to invasion and tumor progression. Here, we identify MAP2K3 as a transcriptional target of endogenous gain-of-function p53 mutants R273H, R175H, and R280K.
Aymone Gurtner, Giuseppe Starace, Giuseppe Norelli, Giulia Piaggio, Ada Sacchi, Gianluca Bossi   +5 more
openalex   +5 more sources

Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line

Poultry Science, 2020
Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj   +1 more source

Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons [PDF]

Journal of Biological Chemistry, 2005
There is accumulating evidence that the p38 MAP kinase pathway plays important roles in Type I interferon (IFN) signaling, but the mechanisms regulating p38 activation during engagement of the Type I IFN receptor remain to be defined. We sought to identify the events that lead to activation of the p38 MAP kinase in response to Type I IFNs.
Yongzhong, Li, Sandeep, Batra, Antonella, Sassano, Beata, Majchrzak, David E, Levy, Matthias, Gaestel, Eleanor N, Fish, Roger J, Davis, Leonidas C, Platanias   +8 more
openaire   +2 more sources

Mitogen‐activated protein kinase/extracellular signal‐regulated kinase attenuates 3‐hydroxykynurenine‐induced neuronal cell death [PDF]

Journal of Neurochemistry, 2004
Abstract3‐Hydroxykynurenine (3‐HK), an endogenous tryptophan metabolite, is known to have toxic effects in brain. However, the molecular mechanism of the toxicity has not been well identified. In this study, we investigated the involvement of MAPK/extracellular signal‐regulated kinase (ERK) in the 3‐HK‐induced neuronal cell damage.
Hyun Jung, Lee, Jae-Hyung, Bach, Hee-Sun, Chae, Sang Hyung, Lee, Wan Seok, Joo, Se Hoon, Choi, Kyung Yong, Kim, Won Bok, Lee, Sung Su, Kim   +8 more
openaire   +2 more sources

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice [PDF]

The EMBO Journal, 1999
The p38 mitogen-activated protein kinase (MAPK) pathway, like the c-Jun N-terminal kinase (JNK) MAPK pathway, is activated in response to cellular stress and inflammation and is involved in many fundamental biological processes. To study the role of the p38 MAPK pathway in vivo, we have used homologous recombination in mice to inactivate the Mkk3 gene,
Lu, Hong-Tao, Yang, Derek D., Wysk, Mark Allen, Gatti, Evelina, Mellman, Ira, Davis, Roger J., Flavell, Richard A.   +6 more
openaire   +3 more sources

PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression

Molecular & Cellular Oncology, 2017
Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-
Leslie Ann Caromile, Linda H. Shapiro
doaj   +1 more source

Expression and Activation of Mitogen-Activated Protein Kinase Kinases-3 and -6 in Rheumatoid Arthritis [PDF]

The American Journal of Pathology, 2004
The p38 mitogen-activated protein (MAP) kinase signal transduction pathway regulates the production of interleukin-1 and tumor necrosis factor-alpha. p38 kinase inhibitors are effective in animal models of arthritis and are currently being developed in rheumatoid arthritis (RA).
Martine, Chabaud-Riou, Gary S, Firestein
openaire   +2 more sources

c-Jun N-terminal Kinase Contributes to Norepinephrine-Induced Contraction Through Phosphorylation of Caldesmon in Rat Aortic Smooth Muscle

Journal of Pharmacological Sciences, 2006
.: Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK).
Youn Ri Lee, Chang-Kwon Lee, Hyo-Jun Park, Hyojin Kim, Junghwan Kim, Jaeheung Kim, Keun Sang Lee, Yun Lyul Lee, Kyung Ok Min, Bokyung Kim   +9 more
doaj   +1 more source