Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks [PDF]
Frontiers in Plant Science, 2020 Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan +3 more
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Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways [PDF]
Journal of Ginseng Research, 2016 Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin +7 more
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Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]
PLoS ONE, 2008 Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay +9 more
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Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
Involvement of protein kinases associated signal transduction mechanisms in cardiac diseases
Exploration of Medicine, 2023 Protein kinases, a family of enzymes responsible for regulating various cellular processes, have been implicated in the development and progression of various heart diseases, making them attractive therapeutic targets.
Jaykrishan Prasad +2 more
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Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids
Frontiers in Bioscience-Landmark, 2021 Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents.
Hanlin Ye +10 more
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Frontiers in Immunology, 2016 Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections.
Peter Epeh Kima, Naixin eZhang
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Effects of MAP4K inhibition on neurite outgrowth
Molecular Brain, 2023 Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in ...
Di Ja Lasham +7 more
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Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
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Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease
Biomolecules, 2023 Colorectal cancer is a known complication of chronic inflammation of the colon (“colitis-associated colon cancer”). Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with IBD are at increased risk
Michelle Temby +4 more
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