Results 1 to 10 of about 400,893 (317)

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
doaj   +1 more source

Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks

Frontiers in Plant Science, 2020
Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan, Lixia Pan, Ive De Smet, Ive De Smet   +3 more
doaj   +1 more source

Involvement of protein kinases associated signal transduction mechanisms in cardiac diseases

Exploration of Medicine, 2023
Protein kinases, a family of enzymes responsible for regulating various cellular processes, have been implicated in the development and progression of various heart diseases, making them attractive therapeutic targets.
Jaykrishan Prasad, Anureet K. Shah, Naranjan S. Dhalla   +2 more
doaj   +1 more source

Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids

Frontiers in Bioscience-Landmark, 2021
Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents.
Hanlin Ye, Linlin Wang, Li Ma, Maksim Ionov, Gan Qiao, Jianlin Huang, Li Cheng, Yuxi Zhang, Xiaohui Yang, Shousong Cao, Xiukun Lin   +10 more
doaj   +1 more source

Leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts

Frontiers in Immunology, 2016
Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections.
Peter Epeh Kima, Naixin eZhang
doaj   +1 more source

Effects of MAP4K inhibition on neurite outgrowth

Molecular Brain, 2023
Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in ...
Di Ja Lasham, Reza K. Arta, Abdul Fuad Hadi, Jun Egawa, Vance P. Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya   +7 more
doaj   +1 more source

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways

Journal of Ginseng Research, 2016
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin, Wei Yang, Dongxu Feng, Xinwen Wang, Muyao Qi, Tianxin Du, Hongzhi Sun, Shufang Wu   +7 more
doaj   +1 more source

Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease

Biomolecules, 2023
Colorectal cancer is a known complication of chronic inflammation of the colon (“colitis-associated colon cancer”). Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with IBD are at increased risk
Michelle Temby, Theresa L. Boye, Jacqueline Hoang, Ole H. Nielsen, John Gubatan   +4 more
doaj   +1 more source

Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis[OPEN]

The Plant Cell, 2018
Multiple pattern-recognition receptors activate mitogen-activated protein kinase cascades and trigger disease resistance in plants via direct phosphorylation and positive feedback regulation.
Guozhi Bi, Zhaoyang Zhou, Weibing Wang, Lin Li, Shaofei Rao, Ying Wu, Xiaojuan Zhang, Frank L. H. Menke, She Chen, Jian‐Min Zhou   +9 more
semanticscholar   +1 more source

Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs

Marine Drugs, 2010
For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins.
Alicia Marquardt, Samuel Abernathy, Jose R. Escalona, Stephen A. Stricker   +3 more
doaj   +1 more source