Results 51 to 60 of about 79,429 (200)

Canaloplasty: current value in the management of glaucoma [PDF]

, 2016
Canaloplasty is a nonpenetrating blebless surgical technique for open-angle glaucoma, in which a flexible microcatheter is inserted within Schlemm's canal for the entire 360 degrees. When the microcatheter exits the opposite end, a 10-0 prolene suture is
Cagini, Carlo, Fiore, Tito, Lippera, Myrta, Lippera, Stefano, Peruzzi, Claudia, Spadea, Leopoldo   +5 more
core   +3 more sources

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12 [PDF]

, 2011
Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours.
Alaniz, Almand, Appay, Barajas, Bell, Beyer, Bluestone, Brodsky, Bronte, Caruso, Catalina Atorrasagasti, Clark, Colombo, Colvin, Croci, Curiel, Dieckmann, Elkord, Ferlay, Flavia Piccioni, Gabrilovich, Gabrilovich, Ghiringhelli, Ghiringhelli, Gomez, Guillermo Mazzolini, Haigh, Huang, Jaime A. Espinoza, Jorge B. Aquino, Juan Bayo, Kerkar, Ko, Larmonier, Laura Alaniz, Leonard, Lorenz, Malvicini, Manuel Gidekel, Mariana Garcia, Mariana Ingolotti, Mariana Malvicini, Matar, Mazzolini, Mazzolini, Mazzolini, Medina-Echeverz, Melero, Nestle, O. Graciela Scharovsky, Onishi, Ormandy, Pablo Matar, Proietti, Putzer, Rabinovich, Sakaguchi, Sangro, Shapira, Spaapen, Suzuki, Takahashi, Tang, Thornton, Trinchieri, Vignali, Yokoyama, Zou, Zou, Zwirner   +69 more
core   +1 more source

Mitomycins syntheses: a recent update [PDF]

Beilstein Journal of Organic Chemistry, 2009
Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. They have been used in clinics since the 1960’s, and the challenges represented by their total synthesis have challenged generations of chemists.
openaire   +4 more sources

Choanal atresia: A review of surgical outcomes in a tertiary medical center

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Introduction Choanal atresia (CA) is a congenital narrowing or obliteration of the posterior nasal aperture. The condition is rare with an incidence of approximately 1 in 5000 to 9000 live births. Objective The aim of this work was to assess the results of treating this condition at the Otolaryngology Department in Oslo University Hospital ...
Sinan Dheyauldeen, Ketil Heimdal, Terje Osnes, Harriet Akre, Lars Olsson   +4 more
wiley   +1 more source

Canaloplasty in the Treatment of Open-Angle Glaucoma: A Review of Patient Selection and Outcomes. [PDF]

, 2018
Canaloplasty is a relatively new non-penetrating surgery for the reduction of intraocular pressure in patients affected by glaucoma. The technique uses a microcatheter to perform a 360 º cannulation of Schlemm's canal and leaves in place a tension suture
Brusini, Paolo, Michelessi, Manuele, Oddone, Francesco, Quaranta, Luciano, Riva, Ivano, Weinreb, Robert N   +5 more
core   +2 more sources

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway

Aging Cell, EarlyView.
Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar   +4 more
wiley   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources

Hyperthermic intraperitoneal chemotherapy after upfront cytoreductive surgery for stage III epithelial ovarian cancer: Follow‐up of long‐term survival

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 988-997, May 2025.
This study provides further evidence supporting the long‐term efficacy of HIPEC for the primary treatment of advanced ovarian cancer. The PCS‐HIPEC approach achieved superior survival outcomes when optimal cytoreduction was possible. Abstract Introduction The survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) has been well defined at
Ziying Lei, Yue Wang, Runya Fang, Ke Wang, Jun Tian, Yangxiao Chen, Yingsi Wang, Jiali Luo, Jinfu He, Binghui Ding, Xianzi Yang, Li Wang, Shuzhong Cui, Hongsheng Tang, for the Chinese Peritoneal Oncology Study group (Gynecologic Oncology Study group)   +14 more
wiley   +1 more source