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Biochemistry (Moscow), 2019
Mitochondria play a crucial role in energy production, general cell metabolism, cell signaling, and apoptosis. Mitochondria are also the main source of reactive oxygen species, especially in the case of their dysfunction. Therefore, damaged or even superfluous mitochondria not required for normal cell functioning represent risk factors and should be ...
D V, Mamaev, R A, Zvyagilskaya
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Mitochondria play a crucial role in energy production, general cell metabolism, cell signaling, and apoptosis. Mitochondria are also the main source of reactive oxygen species, especially in the case of their dysfunction. Therefore, damaged or even superfluous mitochondria not required for normal cell functioning represent risk factors and should be ...
D V, Mamaev, R A, Zvyagilskaya
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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand [PDF]
Cell Metabolism, 2018 Dysregulated mitophagy has been linked to Parkinson’s disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro.
Thomas G McWilliams +2 more
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Excessive mitophagy for anxiety
Neuron, 2021In this issue of Neuron, Duan et al. (2021) identified excessive mitophagy in BLA neurons synapsing onto adBNST neurons as a mechanism for reduced neurotransmission and social defeat-induced anxiety-like behaviors.
Hongsheng, Wang +2 more
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Mitophagy in cardiovascular disease
Clinica Chimica Acta, 2020Cardiovascular disease (CVD) leads to high morbidity and mortality rates worldwide. Accumulating evidence has revealed that mitochondria dysfunction is implicated in CVD, such as atherosclerosis (AS), hypertension, myocardial ischemia-reperfusion (MI/R) injury, myocardial infarction (MI), cardiac hypertrophy, heart failure (HF), dilated cardiomyopathy (
Hong Zhou +3 more
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Mitophagy and Mitochondrial Balance
2014Mitochondria are highly dynamic organelles, with a morphology ranging from small roundish elements to large interconnected networks. This fine architecture has a significant impact on mitochondrial homeostasis, and mitochondrial morphology is highly connected to specific cellular process.
PATERGNANI, Simone, PINTON, Paolo
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Mitophagy in Yeast: A Screen of Mitophagy-Deficient Mutants
2017Mitochondrial autophagy (mitophagy) is a process that selectively degrades mitochondria via autophagy. Recent studies have shown that mitophagy plays an important role in mitochondrial homeostasis by degrading damaged or excess mitochondria. The budding yeast Saccharomyces cerevisiae is a powerful model organism that has been employed to study several ...
Kentaro, Furukawa, Tomotake, Kanki
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Alternative macroautophagy and mitophagy
The International Journal of Biochemistry & Cell Biology, 2014Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by macroautophagy. Mitophagy is associated with various physiological and pathological events such as mitochondrial clearance during terminal differentiation of reticulocytes.
Shigeomi, Shimizu +3 more
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Triggering Mitophagy with Photosensitizers
2019One can utilize light illumination to stimulate mitochondrial reactive oxygen species production through the use of mitochondria-specific photosensitizers. By proper tuning of the light dosage, the methodology permits probing of a multitude of mitochondrial damage responses, including mitophagy. This light-controllable trick offers unique opportunities
Cheng-Wei, Hsieh, Wei Yuan, Yang
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