Results 131 to 140 of about 67,036 (249)

Evaluating AI-Based Mitosis Detection for Breast Carcinoma in Digital Pathology: A Clinical Study on Routine Practice Integration. [PDF]

Diagnostics (Basel)
Simmat C, Guichard L, Sockeel S, Pozin N, Peyret R, Lacroix-Triki M, Miquel C, Gauthier A, Sockeel M, Prévot S.   +9 more
europepmc   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Plate tectonics in the microscopy realm: Molecular insights into morphological variability of Peridinium willei (Peridiniales, Dinophyceae)

TAXON, EarlyView.
Abstract Freshwater Peridinium willei (Peridiniaceae) is globally distributed, but reports linking its morphologies with DNA sequence data remain scarce. The taxonomy of the species, and its infraspecific taxa, remain ambiguous due to the lack of DNA sequence data for the original and type material.
Arwin Ahmadpur, Dana C. Eisenhöld, Eva Facher, Marc Gottschling, Selin Gürkan, Borislava P. Hristova, Johanna Knechtel, Paula M.E. Lehner, Hemingway Nyoka, Paweł M. Owsianny, Chiara Peters, Hélène Reich, Eva Reicheneder, Alexander Rockinger, Cecilia Teodora Satta, Marina Stark, F. Sara Uslu, Anže Žerdoner Čalasan   +17 more
wiley   +1 more source

Micronuclei and Other Nuclear Abnormalities in Patella Limpet as Biomarkers of Cytogenotoxicity in Recreational Port Waters

Environmental Toxicology, EarlyView.
ABSTRACT Over the past decades, the growth in human population and economic activities has led to an increase in maritime traffic. This rise puts additional pressure on marine environments, vessel fuel spills being considered to have a major impact on the ecosystem.
Carlos Valiente‐Diaz, Eva Garcia‐Vazquez, Verónica Soto‐López   +2 more
wiley   +1 more source

In situ monitoring of cell adhesion kinetics using label‐free optical biosensors: Evaluating anticancer potential and selectivity of natural compounds

VIEW, EarlyView.
The limitations of conventional techniques hinder the identification of natural compounds with anticancer potential in terms of speed, throughput, sensitivity, and capability of continuous monitoring of relevant biological effects. Novel label‐free optical biosensors represent new opportunities in the discovery of drug candidates, eliminating these ...
Beatrix Péter, Tim Ausbüttel, Nicolett Kanyo, Péter Joó, Kinga Tóth, Zoltán Szittner, Inna Szekacs, Szilvia Bosze, Gábor M. Kovács, Imre Boldizsár, Robert Horvath   +10 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Keeping Pathologists in the Loop and an Adaptive F1-Score Threshold Method for Mitosis Detection in Canine Perivascular Wall Tumours. [PDF]

Cancers (Basel)
Rai T, Morisi A, Bacci B, Bacon NJ, Dark MJ, Aboellail T, Thomas SA, La Ragione RM, Wells K.   +8 more
europepmc   +1 more source

Mitosis detection in breast cancer pathology images by combining handcrafted and convolutional neural network features. [PDF]

J Med Imaging (Bellingham), 2014
Wang H, Cruz-Roa A, Basavanhally A, Gilmore H, Shih N, Feldman M, Tomaszewski J, Gonzalez F, Madabhushi A.   +8 more
europepmc   +1 more source

A thermoplastic microfluidic platform with integrated electrospun scaffolds for assessing brain cell‐specific drug selectivity

VIEW, EarlyView.
Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa, Laura Palumbo, Martina La Rosa, Antonella Girgenti, Fabio Salvatore Palumbo, Pasquale Picone, Francesco Lopresti, Domenico Nuzzo, Vincenzo La Carruba   +8 more
wiley   +1 more source