Results 61 to 70 of about 5,422 (196)

The Role of Immune Checkpoint Inhibitors in Adrenocortical Carcinoma: Enhancing Post‐Surgical Outcomes and Overcoming Relapse

Medicine Advances, Volume 3, Issue 3, Page 205-208, September 2025.
Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that's usually detected at an advanced stage and has a high recurrence rate despite surgical resection, making treatment challenging. Although mitotane is still the only approved treatment, its poor effectiveness has raised interest in immunotherapy with immune checkpoint inhibitors (ICIs ...
Jawairya Muhammad Hussain, Saim Mahmood Khan, Haiqa Sultan, Diya Rathi, Eyob Mekonnen Woldeyohannes, Zemichael Getu Alemayehu   +5 more
wiley   +1 more source

Safe long-term therapy of Cushing’s syndrome over 37 years with mitotane

Frontiers in Endocrinology
While suggested, surgery is not always possible as a first-line treatment of Cushing’s Disease (CD). In such cases, patients require medical therapy in order to prevent complications resulting from hypercortisolism.
Jonas Seibold, Mario Hönemann, Anke Tönjes, Benjamin Sandner   +3 more
doaj   +1 more source

The Treatment and Follow up of Adrenocortical Carcinoma [Adrenokortikal Karsinomlarda Tedavi Ve Izlem]

Medicine Science, 2015
Adrenocortical carcinoma is a rare endocrine malignancy. Patients present with hormone excess or a local mass effect. The tumor is agressive and characterized by a high risk of recurrence even after complete resection. Recurrence rate (particularly local
Pinar Sisman, Canan Ersoy
doaj   +1 more source

Results of the treatment of adrenocortical cancer patients at the Maria Sklodowska-Curie National Research Institute of Oncology – Krakow Branch

Nowotwory, 2023
INTRODUCTION: Adrenocortical carcinoma (ACC) has an incidence of 1–2 cases per million and the 5-year overall survival (OS) is 16–47%. Surgery is the treatment of choice.
Elżbieta Pluta, Magdalena Michta, Anna Patla, Anna Mucha-Małecka, Krzysztof Wójcicki, Piotr B. Madej   +5 more
doaj   +1 more source

Clinical characteristics, treatment, and outcomes of hypoadrenocorticism in dogs

Journal of Small Animal Practice, Volume 66, Issue 9, Page 627-635, September 2025.
Objectives To determine the long‐term survival of dogs with hypoadrenocorticism during the period that desoxycorticosterone pivalate has become widely used. Secondary goals were to compare age at diagnosis, median survival times, and age at death for dogs with hyponatraemic and/or hyperkalaemic hypoadrenocorticism and eunatraemic eukalaemic ...
T. N. Sherrod, E. Lashnits, K. F. Lunn
wiley   +1 more source

Complications of Cushing's syndrome: state of the art [PDF]

, 2016
Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities.
Biller, Beverly M. K, Colao, Annamaria, De Martino, Maria Cristina, Isidori, Andrea, Newell Price, John, Pivonello, Rosario   +5 more
core   +1 more source

Bilateral Adrenal Ablation for the Treatment of Ectopic ACTH Syndrome With Severe Hypokalemia: A Case Report and a Literature Review

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Ectopic ACTH secretion‐related Cushing's syndrome may manifest as a rapid onset of hypercortisolism, elevated urinary free cortisol (UFC) and blood ACTH concentrations, and hypokalemia. However, for patients whose primary lesions are difficult to remove, bilateral adrenalectomy is the recommended treatment method according to guidelines. Here,
Fang Sun, Yuyu Sun, Hongbo He, Zhigang Zhao, Hexuan Zhang, Nan Jiang, Zhiming Zhu   +6 more
wiley   +1 more source

Powder Self-Emulsifying Drug Delivery System for Mitotane: In Vitro and In Vivo Evaluation

Pharmaceutics
Drug Delivery Systems (DDSs) of known drugs are prominent candidates for new and more effective treatments of various diseases, as they may increase drug solubility, dissolution velocity, and bioavailability.
Mohamed Skiba, Valentin Lefébure, Frederic Bounoure, Nicolas Milon, Michael Thomas, Herve Lefebvre, Lahiani-Skiba Malika   +6 more
doaj   +1 more source

Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients [PDF]

, 2015
Background: Cushing's syndrome (CS) is a severe condition with excess mortality and significant morbidity necessitating control of hypercortisolemia.
Aylwin, S., Ball, S., Boelaert, K., Cheer, K., Chortis, V., Cuthbertson, D.J., Daniel, E., Daousi, C., Davis, J., Drake, W., Grossman, A., Gunganah, K., Gurnell, M., Hill, N., Huguet, I., Karavitaki, N., Kearney, T., Lansdown, A.J., Meeran, K., Minder, A-EH., Mohit, K., Munir, A., Mustafa, O., Newell-Price, J., Powlson, A.S., Rajeev, S.P., Rees, A., Trainer, P.J.   +27 more
core   +2 more sources

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

MedComm, Volume 6, Issue 7, July 2025.
MAM dysfunction is considered as an initiator or contributor in the progression of various diseases such as nervous system diseases, circulatory system diseases, digestive system diseases, locomotor system diseases, reproductive system diseases, endocrine system diseases, urinary system diseases, respiratory system diseases and cancer.
Yong Liu, Zi‐Hui Mao, Junwen Huang, Hui Wang, Xiao Zhang, Xin Zhou, Yue Xu, Shaokang Pan, Dongwei Liu, Zhangsuo Liu, Qi Feng   +10 more
wiley   +1 more source