Results 71 to 80 of about 5,422 (196)
Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth [PDF]
, 2017 PELP1 acts as an estrogen receptor (ER) coactivator that exerts an essential role in the ER's functions. ER coregulators have a critical role in the progression and response to hormonal treatment of estrogen-dependent tumors.
Avena, Paola +7 more
core +2 more sources
A retrospective cohort study of 122 dogs treated for hypercortisolism: low-dose dexamethasone suppression test sensitivity and comparative outcomes in response to mitotane or trilostane [PDF]
Arquivo Brasileiro de Medicina Veterinária e ZootecniaSpontaneous hypercortisolism (HC), a prevalent endocrinopathy among elderly dogs, is mainly confirmed by the low dexamethasone dose suppression test (LDDST).
M.M. Marçal +4 more
doaj +1 more source
Diagnosis and treatment of canine hypoadrenocorticism [PDF]
, 2018 Canine hypoadrenocorticism (Addison’s disease), the ‘great pretender’ of internal medicine, is a disease that should be frequently considered as a differential diagnosis of several clinical presentations, albeit it is less commonly the actual cause of ...
Gunn, Eilidh +2 more
core +1 more source
Clinical Genetics, Volume 107, Issue 6, Page 699-701, June 2025.Collision of monoallelic MUTYH and POLE germline variants in a patient with adrenocortical carcinoma who achieved a strong response to immunotherapy.
Jonathan Lopez +11 more
wiley +1 more source
Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study
International Journal of Endocrinology, 2013 Limited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of ...
Hassan Shawa +6 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 29, Issue 12, June 2025.ABSTRACT Glioma is the most common malignant brain tumor and remains associated with a poor prognosis and limited predictive tools. The dysregulation of RNA processing factor genes has been implicated in glioma development, yet their prognostic relevance remains unclear.
Jiarui Chen +8 more
wiley +1 more source
Therapeutic potential of targeting the FLNA‐regulated Wee1 kinase in adrenocortical carcinomas
International Journal of Cancer, Volume 156, Issue 6, Page 1256-1271, 15 March 2025.What's new? Adrenocortical carcinoma (ACC) is a rare but aggressive cancer of the adrenal gland. In many ACC cases, expression of the cytoskeletal protein filamin A (FLNA) is dramatically reduced; its presence in a tumour is associated with less aggressiveness.
Emanuela Esposito +17 more
wiley +1 more source
Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes
Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari +11 more
wiley +1 more source
Frontiers in PharmacologyBackground and aims: Cancer continues to be a significant source of both illness and death on a global scale, traditional medicinal plants continue to serve as a fundamental resource of natural bioactive compounds as an alternative source of remedies ...
Othman Baothman +10 more
doaj +1 more source
Role of the mTOR pathway in normal and tumoral adrenal cells [PDF]
, 2010 The mammalian target of rapamycin (mTOR) is a kinase of the phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT) signaling pathway, which is one of the most important intracellular mediators of the activity of growth factors receptors ...
Hofland, L.J. (Leo) +3 more
core +1 more source