Results 181 to 190 of about 2,942 (230)

Fasting improves oral bioavailability of mitragynine in healthy female Beagles.

American Journal of Veterinary Research
Objective To evaluate the pharmacokinetic profile and safety of an encapsulated kratom extract when administered orally to fed and fasted healthy female Beagles. Methods The study was conducted over a 24-hour period in June 2023.
Abigail Ortiz, E. Maxwell, Michelle A Kuntz, Abhishek Gour, D. Portela, E. Miscioscia, Judith Bertran, Manraj K Grewal, C. R. McCurdy, Abhisheak Sharma   +9 more
semanticscholar   +1 more source

Analysis of the molecular interaction of mitragynine from kratom with human α1-acid glycoprotein: biophysical and molecular modeling investigations.

Journal of Biomolecular Structure and Dynamics
Mitragynine (MTG), the primary psychoactive alkaloid in Mitragyna speciosa (kratom), has garnered much attention for its therapeutic properties, which is attributed mainly to its selective action on opioid receptors.
Khairul Azreena Bakar, S. Feroz
semanticscholar   +1 more source

Determination of Mitragynine and 7-Hydroxymitragynine in Raw Kratom Plant Material by a Multisegment Injection Capillary Zone Electrophoresis-Tandem Mass Spectrometry.

Journal of Separation Science
A novel validated analytical approach implementing multisegment injection strategy into the capillary zone electrophoresis-tandem mass spectrometry hyphenation for determination of two psychoactive alkaloids, mitragynine (MIT), and 7-hydoxymitraginine (7-
A. Horniakova, P. Mikuš, J. Piešťanský   +2 more
semanticscholar   +1 more source

B-279 False positive results for the CEDIA™ Mitragynine Immunoassay caused by methadone and EDDP in clinical specimens

Clinical Chemistry
Mitragynine is an indole-based opioid-receptor agonist and the most abundant active alkaloid in the plant Mitragyna speciosa, commonly known as kratom.
Zhe Cheng, Lixia Chen
semanticscholar   +1 more source

Comparative Analysis of Mitragynine and Alkaloid Content in Cultivated M. speciosa Leaves and Their α-Glucosidase Inhibitory Activity

TRENDS IN THE SCIENCES
Mitragyna speciosa (kratom) is a Southeast Asian medicinal plant rich in indole and oxindole alkaloids, with mitragynine as its major bioactive component.
N. Chana, Jamjan Pechsiri, Parichat Thepthong, Ratanaporn Pakee, Witsuta Decha, P. Kongsune   +5 more
semanticscholar   +1 more source

Formulation and Delivery of Mitragynine: A Mini Review

Journal of Medicinal Natural Products
Mitragynine is the most abundant psychoactive indole alkaloid found in the leaves of Mitragyna speciosa, which is commonly known as “Kratom”, and is distributed widely in Indonesia, Malaysia, Papua New Guinea, the Philippines, and Thailand. The leaves of
L. Nahar, Satyajit D. Sarker
semanticscholar   +1 more source

Antioxidation, antiglycation, and cytoprotective potential of various kratom (Mitragyna speciosa) leaf extracts and its major alkaloid, mitragynine

Journal of Applied Pharmaceutical Sciences
Oxidative stress and advanced glycation end-products (AGEs) contribute to cellular damage and the progression of chronic diseases. Kratom (Mitragyna speciosa (Korth.) Havil.) has been traditionally used for various therapeutic purposes; however, its ...
Rinnapat Boonsut, J. Wungsintaweekul, C. Premprasert, Narumon Sengnon, Ilham Hama, S. Limsuwanchote   +5 more
semanticscholar   +1 more source

Comparative brain proteome analysis of an Indole Alkaloid of Kratom, Mitragynine and Kratom juice in rats.

Behavioural Brain Research
Mitragyna speciosa, commonly known as kratom, is a medicinal plant that is widely used for various medical conditions. The major alkaloid in kratom is mitragynine which binds partially to opioid receptors to produce opioid-like effects. In this study, we
Sohaib Jumaah Owaid, Suleiman Yunusa, L. Gam, Z. Hassan   +3 more
semanticscholar   +1 more source

B-301 As Xylazine Use Declines, Is Mitragynine Becoming the New Trend in Illicit Drug Use?

Clinical Chemistry
Xylazine is a veterinary sedative primarily used to sedate large animals. Although it is not approved for human use due to its severe effect on the central nervous system, xylazine has increasingly appeared as a drug of abuse.
Hind Malaeb, William Feeney, I. Choucair
semanticscholar   +1 more source

412 Catch Me If You Can: Norbuprenorphine Interference with 7-Hydroxy Mitragynine

American Journal of Clinical Pathology
7-Hydroxy Mitragynine (7OHM) is an emerging drug of abuse due to opioid-like properties. Though 7OHM is a metabolite of Mitragynine (Kratom), taking 7OHM on its own is increasing in popularity.
Alyssa Aebersold, Maria Kern, Delaney Baker, Praveen Alla, L. Edinboro   +4 more
semanticscholar   +1 more source