Results 191 to 200 of about 2,942 (230)

Discriminative stimulus properties of mitragynine (kratom) in rats

Psychopharmacology, 2015
Mitragynine (MG) is the primary active alkaloid extracted from the leaves of Mitragyna speciosa or kratom and exhibits pharmacological activities mediated by opioid receptors. The plant has been traditionally used for its opium and psychostimulant-like effects to increase work efficiency or as a substitute in the self-treatment of opiate addiction.The ...
Harun N, Hassan Z, Navaratnam V, Mansor SM, Shoaib M   +4 more
openaire   +3 more sources

A Case of 7-OH Mitragynine Use Requiring Inpatient Medically Managed Withdrawal.

Journal of addiction medicine
OBJECTIVES There is an increased interest in kratom and kratom-related products such as 7-hydroxymitragynine (7-OH). Here we present the case of a patient seeking inpatient substance use treatment for daily 7-OH use and the clinical course of care ...
Rachel S. Wightman, David Hu
semanticscholar   +1 more source

Abstract 610: Manzamine and mitragynine: investigation of beta carboline compounds from marine sponges and kratom leaves as ovarian cancer therapeutics

Cancer Research
Epithelial ovarian cancer (EOC) is the leading cause of death among gynecologic cancers. Five-year survival rates hover around 35%, largely due to widely metastatic and drug-resistant recurrent disease.
Ashley Gabriel, Haifa Sahouri, H. Fischer, Kimberly A. Gonzalez, Jihad Aburas, Cai M. Roberts   +5 more
semanticscholar   +1 more source

Evaluation of growth position and root associative microbes of Mitragyna speciosa on the production of psychoactive, mitragynine and alkaloids

Notulae Scientia Biologicae
Cultivation of kratom on riparian (Kapuas), is believed to increase leaf phytochemicals. The location of the best land and basis for the identification of red and green kratom is unknown.
Cico Jhon Karunia Simamora, Kiki Prio Utomo, Jumiati, Muhammad Pramulya, Nelly Wahyuni   +4 more
semanticscholar   +1 more source

Mitragynine (Kratom)—Withdrawal behaviour and cognitive impairments can be ameliorated by an epigenetic mechanism

British Journal of Pharmacology
Kratom is a preparation from Mitragyna speciosa, which is used as a natural drug preparation for many purposes around the world. However, an overdose of Kratom may cause addiction‐like problems including aversive withdrawal states resulting in cognitive ...
Suleiman Yunusa, Christian P. Müller, Z. Hassan   +2 more
semanticscholar   +1 more source

Multiple-Dose Pharmacokinetics and Safety of Mitragynine, the Major Alkaloid of Kratom, in Rats.

ACS Pharmacology & Translational Science
This study reports the steady-state pharmacokinetic parameters for mitragynine and characterizes its elimination in male and female rats. Four male and female rats were dosed q12h with 40 mg/kg, and orally administered mitragynine for 5 and 6 days ...
Yi-Hua Chiang, Erin C. Berthold, Michelle A Kuntz, S. R. Kanumuri, Alexandria S. Senetra, Sushobhan Mukhopadhyay, Aidan J. Hampson, Christopher R. McCurdy, Abhisheak Sharma   +8 more
semanticscholar   +1 more source

Pharmacological action of mitragynine

Pharmalogical action of mitragynine, an indole alkaloid from the leaves of Mitragyna speciosa (Korth.) was studied and reported in this dissertation. In mice, it was found that mitragynine, 30 mg/kg, produced significant antinociceptive effect using hot plate test, writhing test and formalin test in a dose dependent manner.
openaire   +1 more source

Binding characteristics of the major kratom alkaloid, mitragynine, towards serum albumin: spectroscopic, calorimetric, microscopic, and computational investigations.

Chemico-Biological Interactions
Mitragynine (MTG) is a prominent indole alkaloid that is present abundantly in Mitragyna speciosa, commonly referred to as kratom. MTG has garnered significant attention due to its selective agonistic characteristics towards opioid receptors and related ...
Khairul Azreena Bakar, Su Datt Lam, S. Feroz   +2 more
semanticscholar   +1 more source

Postmortem distribution of mitragynine and 7-hydroxymitragynine in 51 cases.

Journal of Analytical Toxicology
The prevalence of mitragynine (kratom) in forensic toxicology casework has steadily increased over time. Readily available and currently legal, mitragynine is widely used for its stimulant and, depending on concentration, sedative effects. Our laboratory
Kei A Osawa, Robert D. Johnson
semanticscholar   +1 more source

The Associations of Kratom (Mitragynine), Opioids, Other Substances, and Sociodemographic Variables to Drug Intoxication–related Mortality

Journal of addiction medicine
Introduction: The US age-adjusted drug overdose rate increased by 298%, with fentanyl being the main contributor to drug overdose deaths. The contribution of kratom to drug overdoses or intoxication is seldom reported despite its increasing use and ...
Armiel A. Suriaga, Ruth M. Tappen, Christopher R McCurdy, David Newman, Oliver Grundmann, John F Kelly   +5 more
semanticscholar   +1 more source