Results 71 to 80 of about 219,022 (300)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mixed-Criticality Scheduling with I/O [PDF]

, 2016
This paper addresses the problem of scheduling tasks with different criticality levels in the presence of I/O requests. In mixed-criticality scheduling, higher criticality tasks are given precedence over those of lower criticality when it is ...
Katherine Missimer, Missimer, Katherine, Richard West, Eric Missimer, Missimer, Eric, West, Richard   +5 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Towards the Design of Certifiable Mixed-criticality Systems

2010 16th IEEE Real-Time and Embedded Technology and Applications Symposium, 2010
Many safety-critical embedded systems are subject to certification requirements; some systems may be required to meet multiple sets of certification requirements, from different certification authorities. Certification requirements in such "mixed-criticality" systems give rise to some interesting scheduling problems, that cannot be satisfactorily ...
S.K. Baruah (Sanjoy), H. Li, L. Stougie (Leen)   +2 more
openaire   +2 more sources

Enhancing Performance in Mixed‐Criticality Real‐Time Systems Through Learner‐Based Resource Management

IET Cyber-Physical Systems
In mixed‐criticality (MC) systems, tasks with varying criticality levels share resources, leading to challenges in resource management during mode transitions.
Mohammadreza Saberikia, Hakem Beitollahi, Rasool Jader, Hamed Farbeh   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mixed Criticality Systems with Varying Context Switch Costs

, 2018
In mixed criticality systems, it is vital to ensure that there is sufficient separation between tasks of LO- and HI-criticality applications, so that the behavior or mis-behavior of the former cannot affect the functional or timing correctness of the ...
Burns, A., Pellizzoni, R., Altmeyer, S., Davis, R.I.   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Extending eXsched with mixed criticality support - An experience report

, 2017
This paper describes our experience with extending ExSched, an operating system independent external CPU scheduler framework for real-time systems, with support for mixed criticality.
Reinder J. Bril, Gupta, T Tarun, van de Heuvel, M.M.H.P., Bril, R.J., Tarun Gupta, Erik J. Luit, Gupta, T., Heuvel, MMHP Martijn van den, Martijn M.H.P. v.d. Heuvel, Bril, RJ Reinder, Luit, EJ Erik, Luit, E.J.   +11 more
core   +1 more source