Results 81 to 90 of about 3,283 (262)

Integrating Multi-Level Mixed-Criticality into MCTS for Robust Resource Management [PDF]

Leibniz Transactions on Embedded Systems
Managing actions with uncertain resource costs is a complex challenge, particularly in autonomous robot mission planning. Robots are often assigned multiple objectives with varying criticality levels, ranging from catastrophic to minor impacts, where ...
Cordeiro, Franco, Tardieu, Samuel, Pautet, Laurent   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ground state solutions of nonlocal equations with variable exponents and mixed criticality

Boundary Value Problems
In this article, we use approximation techniques and variational methods to study a class of nonlocal equations with variable exponents and mixed criticality. We prove the existence of the ground state nontrivial solutions with the least energy.
Yuhang Long, Xingwen Chen, Qiongfen Zhang   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Transmission scheduling for mixed-critical multi-user multiple-input and multiple-output industrial cyber-physical systems

International Journal of Distributed Sensor Networks, 2017
Wireless sensor networks are widely used in industrial cyber-physical system installations, where high reliability and the need for real-time data are the two main characteristics. A large amount of real-time data can be transmitted to its destination on
Changqing Xia, Xi Jin, Linghe Kong, Jintao Wang, Peng Zeng   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

GSN Support of Mixed-Criticality Systems Certification [PDF]

, 2017
Safety-critical applications could benefit from the standardisation, cost reduction and cross-domain suitability of current heterogeneous computing platforms. They are of particular interest for Mixed-Criticality Product Lines (MCPL) where safety- and non-safety functions can be deployed on a single embedded device using suitable isolation artefacts ...
Carlos Fernando Nicolás, Fernando Eizaguirre, Asier Larrucea, Simon Barner, Franck Chauvel, Goiuria Sagardui, Jon Pérez 0001   +6 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source