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Cytochrome P-450 and Mixed-Function Oxygenase Systems in Marine Invertebrates
, 2018 R. Lee, Linda C. Quattrochi
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The influence of pregnenolone-16α-carbonitrile on hepatic mixed-function oxygenases
Steroids, 1971Summary 3β-hydroxy-20-oxo-5-pregnene-16α-carbonitrile [Pregnenolone-16α-carbonitrile (PCN)] unlike the naturally-occurring steroid pregnenolone, enhances the plasma clearance of pentobarbital, and elicits a corresponding increase in the production of 14C-pentobarbital metabolites as well as in liver weight, microsomal protein concentration, NADPH ...
B, Solymoss, J, Werringloer, S, Toth
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Comparison of liver mixed-function oxygenase and antioxidant enzymes in vertebrates
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2004We performed a comparative analysis of cytochrome P450, cytochrome b5, MFO associated enzymes and cytosolic antioxidant enzymes in hepatic microsomes and cytosolic fractions prepared from five animal species representing three vertebrate classes living in tropical conditions (Brazil).
Thomaz A A, Rocha-e-Silva +5 more
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USE OF MIXED-FUNCTION OXYGENASES TO MONITOR CONTAMINANT EXPOSURE IN WILDLIFE
Environmental Toxicology and Chemistry, 1989Abstract This overview examines the utility of mixed-function oxygenase (MFO) enzymes as a bio-effects monitor for wildlife (amphibians, reptiles, birds and mammals) in view of their widespread use as indicators of contaminant exposure in aquatic invertebrates and fish.
Barnett A. Rattner +2 more
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Mixed-function oxygenase system and benzo[a]pyrene metabolism in echinoderms
Marine Environmental Research, 1989Abstract A comparative study on the presence of a mixed-function oxygenase (MFO) system was carried out on four echinoderm species: the asteroids Asterias rubens and Marthasterias glacialis , an echinoid Echinus esculentus and a holothurian Holothuria forskali . In A.
Pieter J. den Besten +1 more
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The interplay between mixed function oxygenases and DNA alteration under PAH pollution
Marine Environmental Research, 1985Abstract Our experience in DNA alteration assessment tells us that aquatic vertebrates, in general, and also some of the invertebrates, by living in polluted areas acquire altered DNA; DNA alterations being defined either as single-strand breaks, and/or alkali sensitive or single-strand specific nuclease-cleavable sites (sse).
R.K. Zahn +5 more
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Presence of mixed function oxygenase in some marine invertebrates
Thalassia Jugoslavica, 1983We could confirm MFO activity in crabs at the levelswhich are low compared to the activity levels found in vertebrates. MFO inducibility by Diesel-2 oil and benzo(a)pyrene was demonstrated in crab Pilumnus spinifer.
Kurelec, Branko +2 more
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Journal of Urology, 1982
The responsiveness of BCNU treated mice to phenobarbital (Pb) induction of hepatic microsomal mixed function oxygenase (MFO) activity was studied. BCNU (30 mg/kg ip) produced significant (P less than 0.05) decreases in cytochrome P-450, total ethylmorphine metabolism (TEM) and ethylmorphine N-demethylase (EMN) by 21 days after treatment.
V L, Wilson, R E, Larson
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The responsiveness of BCNU treated mice to phenobarbital (Pb) induction of hepatic microsomal mixed function oxygenase (MFO) activity was studied. BCNU (30 mg/kg ip) produced significant (P less than 0.05) decreases in cytochrome P-450, total ethylmorphine metabolism (TEM) and ethylmorphine N-demethylase (EMN) by 21 days after treatment.
V L, Wilson, R E, Larson
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Archives of Environmental Contamination and Toxicology, 1983
The effects of the environmental pollutant benzo(a)pyrene (BP) were assessed on the hepatic mixed function oxygenase system (MFO) in the channel catfish,Ictalurus punctatus. Initially, the optimum conditions were established for measuring hepatic MFO in this species of fish.
S W, Fingerman +3 more
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The effects of the environmental pollutant benzo(a)pyrene (BP) were assessed on the hepatic mixed function oxygenase system (MFO) in the channel catfish,Ictalurus punctatus. Initially, the optimum conditions were established for measuring hepatic MFO in this species of fish.
S W, Fingerman +3 more
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Sex differences in cytochrome P-450 and mixed-function oxygenase activity in gonadally mature trout
Biochemical Pharmacology, 1980Abstract Levels of microsomal cytochrome P-450 and aminopyrine demethylase activity in liver and of cytochrome P-450 in kidney of gonadally mature rainbow and brook trout were markedly greater in males than in females. Similar differences appeared in hepatic microsomal NADH- but not in NADPH-cytochrome c reductase activity or cytochrome b 5 ...
J J, Stegeman, M, Chevion
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