MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis. [PDF]
J Nanobiotechnology, 2020 Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy.
Lan Q +9 more
europepmc +6 more sources
Notch Signaling Regulates MMP-13 Expression via Runx2 in Chondrocytes. [PDF]
Sci Rep, 2019 Notch signaling is involved in the early onset of osteoarthritis. The aim of this study was to investigate the role of Notch signaling changes during proliferation and differentiation of chondrocyte, and to testify the mechanism of MMP-13 regulation by ...
Xiao D +5 more
europepmc +5 more sources
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. [PDF]
Int J Mol Sci, 2021 Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues.
Hu Q, Ecker M.
europepmc +2 more sources
The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes. [PDF]
Int J Mol Sci, 2022 Severe periodontitis, a destructive inflammatory disease of the supporting tissues of the teeth, ranks sixth in terms of global spread, affecting about 11% of the population.
Luchian I +4 more
europepmc +2 more sources
An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13
BioTechniques, 2017 Collagen zymography is an SDS-PAGE–based method for detecting both the proenzyme and active forms of collagenases. Although collagen zymography is used for assessment of the matrix metalloproteinases MMP-1 and MMP-13, it can be difficult to detect these ...
Seniz Inanc, Didem Keles, Gulgun Oktay
doaj +2 more sources
Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13 [PDF]
Scientific Reports, 2023 Osteoarthritis (OA) is the most common joint disease associated with articular cartilage destruction. Matrix metalloproteinase-13 (MMP-13) has an essential role in OA pathogenesis by degradation of collagen II, a major component of articular cartilage ...
Aya Miyauchi +7 more
doaj +2 more sources
Frontiers in Immunology, 2017 Regulated on activation, normal T expressed, and secreted (RANTES)/CC ligand 5 (CCL5) participates in rheumatoid arthritis (RA) pathogenesis by facilitating leukocyte infiltration, however, its other pathological functions are not fully defined in RA. In
Solomon A. Agere +4 more
doaj +2 more sources
MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients [PDF]
Diagnostics, 2023 Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us with a more accurate view of the evolution, prognosis, and future quality of life for these patients. Our aim was to analyze the presence
Mihail Virgil Boldeanu +12 more
doaj +2 more sources
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation. [PDF]
Sci Rep, 2020 Paclitaxel induces peripheral neuropathy as a side effect of cancer treatment. The underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be the first to degenerate.
Cirrincione AM +8 more
europepmc +2 more sources
Circ_0136474 and MMP-13 suppressed cell proliferation by competitive binding to miR-127-5p in osteoarthritis. [PDF]
J Cell Mol Med, 2019 Osteoarthritis (OA) is a prevalent degenerative joint disease whose pathogenesis remains unclear. The research aims to investigate the roles of Circ_0136474/miR‐127‐5p/MMP‐13 axis in OA. Differentially expressed circRNAs and miRNAs in OA cartilage tissue
Li Z +8 more
europepmc +2 more sources