Results 1 to 10 of about 157,942 (186)

Indole Inhibitors of MMP-13 for Arthritic Disorders [PDF]

ACS Omega, 2021
Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochemical properties to qualify as tool compounds suitable for in vivo testing.
Steven J. Taylor, Asitha Abeywardane, Shuang Liang, Zhaoming Xiong, John R. Proudfoot, Bennett Sandy Farmer, Donghong A. Gao, Alexander Heim-Riether, Lana Louise Smith-Keenan, Ingo Muegge, Yang Yu, Qiang Zhang, Donald Souza, Mark Panzenbeck, Daniel Goldberg, Melissa Hill-Drzewi, Mariana Margarit, Brandon Collins, John Xiang Li, Ljiljana Zuvela-Jelaska, Jun Li, Neil A. Farrow   +21 more
doaj   +5 more sources

Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness? [PDF]

Diagnostic Pathology, 2008
Background Matrix metalloproteinases (MMPs) play an important role in the modeling and remodeling of the extracellular matrix in both physiologic and pathologic states and thus plays an important role in tumor progression. Human collagenase-3 (MMP-13) is
Shamaa Ali A, Zyada Manal M
doaj   +2 more sources

Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13 [PDF]

Scientific Reports, 2023
Osteoarthritis (OA) is the most common joint disease associated with articular cartilage destruction. Matrix metalloproteinase-13 (MMP-13) has an essential role in OA pathogenesis by degradation of collagen II, a major component of articular cartilage ...
Aya Miyauchi, Masahito Noguchi, Xiao-Feng Lei, Masashi Sakaki, Momoko Kobayashi-Tanabe, Shogo Haraguchi, Akira Miyazaki, Joo-ri Kim-Kaneyama   +7 more
doaj   +2 more sources

MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients [PDF]

Diagnostics, 2023
Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us with a more accurate view of the evolution, prognosis, and future quality of life for these patients. Our aim was to analyze the presence
Mihail Virgil Boldeanu, Lidia Boldeanu, Oana Mariana Cristea, Dana Alexandra Ciobanu, Sabin Ioan Poenariu, Anda Lorena Dijmărescu, Andreea Lili Bărbulescu, Vlad Pădureanu, Teodor Nicuşor Sas, Ștefan Cristian Dinescu, Florentin Ananu Vreju, Horațiu Valeriu Popoviciu, Răzvan Adrian Ionescu   +12 more
doaj   +2 more sources

Clinical value of microRNA-135a and MMP-13 in colon cancer. [PDF]

Oncol Lett, 2021
The aim of the present study was to investigate the expression and prognostic value of microRNA-135a (miR-135a) and matrix metalloproteinase-13 (MMP-13) in serum of colon cancer (CC). A total of 117 cases of patients admitted to Sheng Li Oil Field Central Hospital from May 2015 to May 2017 were enrolled in the research group (RG), and 120 cases of ...
Zhou X, Yang D, Ding X, Xu P.
europepmc   +4 more sources

Collagenase-3 (MMP-13) Expression in Cutaneous Malignant Melanoma

The International Journal of Biological Markers, 2005
Background Matrix metalloproteases (MMPs), enzymes with the ability to degrade the extracellular matrix, play an important role in tissue invasion by cutaneous malignant melanoma (CMM).
M.D. Corte, L.O. Gonzalez, M.G. Corte, I. Quintela, I. Pidal, M. Bongera, F. Vizoso   +6 more
doaj   +3 more sources

MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis. [PDF]

J Nanobiotechnology, 2020
Abstract Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), which enables
Lan Q, Lu R, Chen H, Pang Y, Xiong F, Shen C, Qin Z, Zheng L, Xu G, Zhao J.   +9 more
europepmc   +5 more sources

Notch Signaling Regulates MMP-13 Expression via Runx2 in Chondrocytes. [PDF]

Sci Rep, 2019
AbstractNotch signaling is involved in the early onset of osteoarthritis. The aim of this study was to investigate the role of Notch signaling changes during proliferation and differentiation of chondrocyte, and to testify the mechanism of MMP-13 regulation by Notch and Runx2 expression changes during osteoarthritis.
Xiao D, Bi R, Liu X, Mei J, Jiang N, Zhu S.   +5 more
europepmc   +4 more sources

Potential Value of Matrix Metalloproteinase-13 as a Biomarker for Osteoarthritis

Frontiers in Surgery, 2021
Background: Emerging knowledge has highlighted the role of matrix metalloproteinase (MMP)-13 in osteoarthritis (OA); however, the suitability of MMP-13 as a biomarker for OA remains unclear.
Xing Xin, Qizhao Tan, Fang Li, Zhongqiang Chen, Ke Zhang, Feng Li, Feng Li, Bin Yang, Zhili Xing, Fang Zhou, Fang Zhou, Yun Tian, Yun Tian, Yang Lv, Yang Lv, Tengjiao Zhu, Tengjiao Zhu   +16 more
doaj   +1 more source

Disrupting mechanical homeostasis promotes matrix metalloproteinase-13 mediated processing of neuron glial antigen 2 in mandibular condylar cartilage [PDF]

European Cells & Materials, 2023
Post-traumatic osteoarthritis in the temporomandibular joint (TMJ OA) is associated dysfunctional cellmatrix mediated signalling resulting from changes in the pericellular microenvironment after injury.
M Bagheri Varzaneh, Y Zhao, J Rozynek, M Han, DA Reed   +4 more
doaj   +1 more source