Results 71 to 80 of about 396,778 (337)

AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer [PDF]

, 2016
The receptor tyrosine kinase AXL promotes migration, invasion, and metastasis. Here, we evaluated the role of AXL in endometrial cancer. High immunohistochemical expression of AXL was found in 76% (63/83) of advanced-stage, and 77% (82/107) of high-grade
Arif, Batool, Bligard, Katherine H, Desai, Riva A, Divine, Laura M, Fuh, Katherine C, Hagemann, Andrea R, Hagemann, Ian S, Massad, Maria, McCourt, Carolyn K, Meller, Eric, Meyerson, Cherise, Mutch, David G, Nguyen, Mai R, Powell, Matt A, Rankin, Erinn B, Thaker, Premal H   +15 more
core   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Regulation of the ratio of neurotransmitters and matrix metalloproteinases is a new strategy for secondary prevention of patients with multifocal atherosclerosis

Сучасні медичні технології
Multifocal atherosclerosis (MAS) remains one of the key problems of modern medicine, despite advances in primary and secondary prevention of myocardial infarction (MI) and ischemic stroke (IS).
T. M. Motsak, V. G. Lyzogub, O. H. Kupchynska   +2 more
doaj   +1 more source

Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]

, 2011
Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Bauer AT, Broderick JP, Burggraf D, Claassen J, Clark AW, Doczi T, Dzwonek J, Feiler S, Fukuda S, Gasche Y, Guo Z, Jadhav V, Karsten Schöller, Mandal M, Mun-Bryce S, Nikolaus Plesnila, Rosenberg GA, Rosenberg GA, Rosenberg GA, Rosenberg GA, Schöller K, Sehba FA, Serge C. Thal, Sergej Feiler, Stanley JR, Stefan Zausinger, Thal SC, Vu TH, Wang X, Zausinger S   +29 more
core   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer [PDF]

, 1998
The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients.
Allgayer, Heike, Babic, Rudolf, Beyer, Bianca C. M., Grützner, Klaus-Uwe, Heiss, Markus Maria, Schildberg, Friedrich Wilhelm, Tarabichi, Anwar   +6 more
core   +1 more source

Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3 [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2010
European Journal of Nuclear Medicine and Molecular Imaging, 37 (8)
Pfaffen, Stefanie, Frey, Katharina, Stutz, Irène, Roesli, Christoph, Neri, Dario   +4 more
openaire   +4 more sources

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk

Arthritis Care &Research, EarlyView.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase‐7 (MMP‐7), and serum anti–malondialdehyde‐acetaldehyde (anti‐MAA) antibody for rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) risk stratification.
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin

Cells, 2019
The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells.
Selene Pérez-García, Mar Carrión, Irene Gutiérrez-Cañas, Raúl Villanueva-Romero, David Castro, Carmen Martínez, Isidoro González-Álvaro, Francisco J. Blanco, Yasmina Juarranz, Rosa P. Gomariz   +9 more
doaj   +1 more source

MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment [PDF]

, 2016
Matrix metalloproteinase-3 (MMP-3) is known to mediate neuroinflammatory processes by activating microglia, disrupting blood-central nervous system barriers and supporting neutrophil influx into the brain. In addition, the posterior part of the eye, more
Becker, Claude Libert, De Vos, Eichler, Evy Lefevere, Fuentes, Gearing, Goureau, Hoekzema, Hoekzema, Inge Van Hove, Jurgen Sergeys, Kaplanski, Kyriakis, Lies De Groef, Lieve Moons, Manuel Salinas-Navarro, Nemzek, Noble, Planck, Roosmarijn Vandenbroucke, Russ, Sudharshan, Suzuki, Tuaillon, Yadav, Zech   +26 more
core   +2 more sources