Results 61 to 70 of about 390,769 (349)

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

OncoTarget, 2014
Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer development and progression. While many of the different MMPs expressed in breast cancer are produced by stromal cells MMP-9 is produced mainly by the tumor cells ...
Christine Mehner, Alexandra Hockla, Erin Miller, S. Ran, D. Radisky, E. Radisky   +5 more
semanticscholar   +1 more source

Role of Matrilysins (MMP-7, MMP-26) and Stromelysins (MMP-3, MMP-10) in Diagnosing Cervical Cancer Patients

Biomedicines
Background/Objectives: Detection of cervical lesions is crucial for effective prevention and treatment. Therefore, the search for new diagnostic markers is extremely important. This study aimed to evaluate the concentration and diagnostic utility of selected matrix metalloproteinases (MMPs) as novel biomarkers. Methods: The study group consisted of 320
Ewa Gacuta, Michał Ławicki, Hanna Grabowska, Paweł Ławicki, Monika Kulesza, Aleksandra Kicman, Monika Zajkowska, Piotr Laudański, Sławomir Ławicki   +8 more
openaire   +3 more sources

FL-MMP-2 and NTT-MMP-2 expression in renal biopsies of human controls and diabetic nephropathy.

, 2017
Panel I: qPCR measurement of FL-MMP-2 and NTT-MMP-2 transcript abundance in renal biopsies from controls and patients with diabetic nephropathy (DM).
Sun Sik Bae (284124), Harin Rhee (771815), David H. Lovett (173834), Eun Young Seong (230904), Sang Soo Kim (1233510), Min Young Lee (787049), Soo Bong Lee (771821), Sang Heon Song (607351), Dong Won Lee (771820), Ihm Soo Kwak (771822), Nari Shin (3727207), Il Young Kim (771819)   +11 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Overexpression of MMP Family Members Functions as Prognostic Biomarker for Breast Cancer Patients: A Systematic Review and Meta-Analysis

PLoS ONE, 2015
Background Matrix metalloproteinases (MMPs) are regarded to be relevant to the prognosis of breast cancer. Numerous studies have confirmed the association between MMPs and tumor growth, invasion and metastasis in breast cancer.
Fanghui Ren, Rui-Xue Tang, Xin Zhang, Wickramaarachchi Mihiranganee Madushi, Dianzhong Luo, Yi-Wu Dang, Zu-Yun Li, Kang-Lai Wei, Gang Chen   +8 more
semanticscholar   +1 more source

Regulation of matrix-metalloproteinase 9 (MMP-9) in glomerular mesangial cells [PDF]

, 2004
Remodeling of extracellular matrix (ECM) is an important physiologic feature of normal growth and development. In addition to this critical function in physiology many diseases have been associated with an imbalance of ECM synthesis and degradation.
Akool, El-Sayed
core  

Correlation between tissue total-MMP-2, tissue pro-MMP-2 and tissue active- MMP-2 and ascending aortic diameter.

, 2016
Different MMP-2 isoforms were correlated to ascending aortic diameter to test, whether a certain MMP-2 isoform can represent changing mechanical properties in the expanding aortic wall. rS = Spearman correlation coefficient; AU: Arbitrary units.
Claudia Heilmann (3324639), Friedhelm Beyersdorf (3324636), Fabian A. Kari (3324648), Nadja Kocher (3324633), Philipp Meffert (3324645), Xenia Uffelmann (3324651), Matthias Siepe (3324630), Anke Tscheuschler (51872), Philipp Discher (3324642)   +8 more
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Impact of Rurality on Total Joint Arthroplasty Access and Outcomes: A Systematic Review

Arthroplasty Today
Background: Total joint arthroplasty (TJA) is one of the most frequent orthopaedic surgeries in the United States; however, disparities in utilization and outcomes based on race, sex, and socioeconomic level have been well documented. The impact of rural
Sean L. Agrodnia, BA, Catherine M. Call, MD, Andrew D. Lachance, MD, John C. McDonald, MD, Adam J. Rana, MD, Brian J. McGrory, MD, MS   +5 more
doaj   +1 more source

28-Hydroxy-3-oxoolean-12-en-29-oic Acid, a Triterpene Acid from Celastrus Orbiculatus Extract, Inhibits the Migration and Invasion of Human Gastric Cancer Cells In Vitro

Molecules, 2019
Gastric cancer is the fifth most common tumor and has the third-highest mortality rate among various malignant tumors, and the survival rate of patients is low.
Zewen Chu, Haibo Wang, Tengyang Ni, Li Tao, Liangliang Xiang, Zhen Zhou, Yayun Qian, Masataka Sunagawa, Yanqing Liu   +8 more
doaj   +1 more source