Results 41 to 50 of about 240,787 (310)

Induction of renal expression of FL-MMP-2 and NTT-MMP-2 in diabetic mice.

, 2017
Diabetes mellitus was induced in C57/BL6 male mice by daily injection of streptozotocin (40 mg/kg) for five days. Panel I A: Gelatin zymography of renal cortical extracts from control and diabetic mice (24 weeks).
Sun Sik Bae (284124), Harin Rhee (771815), David H. Lovett (173834), Eun Young Seong (230904), Sang Soo Kim (1233510), Min Young Lee (787049), Soo Bong Lee (771821), Sang Heon Song (607351), Dong Won Lee (771820), Ihm Soo Kwak (771822), Nari Shin (3727207), Il Young Kim (771819)   +11 more
core   +1 more source

acdh-oeaw/mmp: new API output

, 2022
What's Changed fix: fix typo in ethnonym autocomplete endpoint by @stefanprobst in https://github.com/acdh-oeaw/mmp/pull/126 build: add openapi schema view by @stefanprobst in https://github.com/acdh-oeaw/mmp/pull/128 115 entity response payloads should
Daniel Stoxreiter, Peter Andorfer, stefanprobst, Marc   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2020
Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential.
Nguyen Nguyet Hong, Cao Ha Tim, Nguyen Chi Dung, Dinh Minh Hiep, Ngo Ke Suong   +4 more
doaj   +1 more source

Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells

Pharmaceutical Biology, 2021
Context Bufadienolide compounds occur in many plants and animal species and have strong cardiac and anti-inflammatory properties. The compounds have been recently investigated for cytotoxic and antitumor activity.
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J. Renata Ochocka   +5 more
doaj   +1 more source

FL-MMP-2 and NTT-MMP-2 expression in renal biopsies of human controls and diabetic nephropathy.

, 2017
Panel I: qPCR measurement of FL-MMP-2 and NTT-MMP-2 transcript abundance in renal biopsies from controls and patients with diabetic nephropathy (DM).
Sun Sik Bae (284124), Harin Rhee (771815), David H. Lovett (173834), Eun Young Seong (230904), Sang Soo Kim (1233510), Min Young Lee (787049), Soo Bong Lee (771821), Sang Heon Song (607351), Dong Won Lee (771820), Ihm Soo Kwak (771822), Nari Shin (3727207), Il Young Kim (771819)   +11 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Correlation between tissue total-MMP-2, tissue pro-MMP-2 and tissue active- MMP-2 and ascending aortic diameter.

, 2016
Different MMP-2 isoforms were correlated to ascending aortic diameter to test, whether a certain MMP-2 isoform can represent changing mechanical properties in the expanding aortic wall. rS = Spearman correlation coefficient; AU: Arbitrary units.
Claudia Heilmann (3324639), Friedhelm Beyersdorf (3324636), Fabian A. Kari (3324648), Nadja Kocher (3324633), Philipp Meffert (3324645), Xenia Uffelmann (3324651), Matthias Siepe (3324630), Anke Tscheuschler (51872), Philipp Discher (3324642)   +8 more
core   +1 more source