Results 51 to 60 of about 390,769 (349)

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

PLoS Pathogens, 2015
Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as
C. Ong, P. Elkington, S. Brilha, C. Ugarte-Gil, M. Tomé-Esteban, L. Tezera, Przemyslaw J. Pabisiak, R. Moores, T. Sathyamoorthy, V. Patel, R. Gilman, Joanna C. Porter, J. Friedland   +12 more
semanticscholar   +1 more source

Induction of renal expression of FL-MMP-2 and NTT-MMP-2 in diabetic mice.

, 2017
Diabetes mellitus was induced in C57/BL6 male mice by daily injection of streptozotocin (40 mg/kg) for five days. Panel I A: Gelatin zymography of renal cortical extracts from control and diabetic mice (24 weeks).
Sun Sik Bae (284124), Harin Rhee (771815), David H. Lovett (173834), Eun Young Seong (230904), Sang Soo Kim (1233510), Min Young Lee (787049), Soo Bong Lee (771821), Sang Heon Song (607351), Dong Won Lee (771820), Ihm Soo Kwak (771822), Nari Shin (3727207), Il Young Kim (771819)   +11 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2020
Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential.
Nguyen Nguyet Hong, Cao Ha Tim, Nguyen Chi Dung, Dinh Minh Hiep, Ngo Ke Suong   +4 more
doaj   +1 more source

Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells

Pharmaceutical Biology, 2021
Context Bufadienolide compounds occur in many plants and animal species and have strong cardiac and anti-inflammatory properties. The compounds have been recently investigated for cytotoxic and antitumor activity.
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J. Renata Ochocka   +5 more
doaj   +1 more source

MMP generated Matrikines

Matrix Biology, 2015
Matrikines originate from the fragmentation of extracellular matrix proteins and regulate cellular activities by interacting with specific receptors.
J. Wells, A. Gaggar, J. Blalock
semanticscholar   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

acdh-oeaw/mmp: new API output

, 2022
What's Changed fix: fix typo in ethnonym autocomplete endpoint by @stefanprobst in https://github.com/acdh-oeaw/mmp/pull/126 build: add openapi schema view by @stefanprobst in https://github.com/acdh-oeaw/mmp/pull/128 115 entity response payloads should
Daniel Stoxreiter, Peter Andorfer, stefanprobst, Marc   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source