Results 71 to 80 of about 390,769 (349)
Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9*
Journal of Biological Chemistry, 2015 Background: Abnormal accumulation of Aβ in the brain is associated with neurodegeneration in Alzheimer disease. Results: Proteolytic degradation of Aβ by MMP-2/MMP-9 sequentially generates highly soluble, nontoxic, and nonfibrillogenic C-terminally ...
M. Hernández-Guillamon +6 more
semanticscholar +1 more source
The FL-MMP-2 and NTT-MMP-2 isoforms are expressed within the same tubular segments.
, 2017 Serial sections of kidneys with diabetic nephropathy were stained with PAS (A) and by immunohistochemistry for FL-MMP-2 (B) and NTT-MMP-2 (C). Staining for both isoforms is prominent within dilated tubules and occurs in the same tubular segments (arrows,
Sun Sik Bae (284124) +11 more
core +1 more source
acdh-oeaw/mmp: UseCase.published adde, Stelle.ort removed
, 2023 What's Changed 192 remove stelleort by @csae8092 in https://github.com/acdh-oeaw/mmp/pull/193 feat: added UseCase.published field #191 by @csae8092 in https://github.com/acdh-oeaw/mmp/pull/194 Full Changelog: https://github.com/acdh-oeaw/mmp/compare/v3.
Daniel Stoxreiter +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai +13 more
wiley +1 more source
MMP-9 and uPAR regulated glioma cell migration [PDF]
, 2012 Integrin dependent and independent MMP-9 and uPAR signaling plays a key role in glioma cell migration and invasion. In this article, we comment on all the possible pathways and molecules associated with MMP-9- and uPAR- mediated glioma cell migration ...
Krishna Kumar Veeravalli (7947389) +1 more
core +4 more sources
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression
Cancers, 2014 Since its original identification as a leukocyte gelatinase/type V collagenase and tumour type IV collagenase, gelatinase B/matrix metalloproteinase (MMP)-9 is now recognised as playing a central role in many aspects of tumour progression. In this review,
A. Farina, A. Mackay
semanticscholar +1 more source
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke [PDF]
Journal of Clinical Medicine, 2019 Ischemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted genetic risk score (wGRS) from these three genes and ...
Hsieh, Fang-I +6 more
openaire +2 more sources
MMP-8, MMP-9 and Neutrophil Elastase in Peripheral Blood and Exhaled Breath Condensate in COPD
, 2017 Chronic obstructive pulmonary disease (COPD) is characterised by progressive and irreversible airflow limitation associated with chronic inflammation involving cytokines and metalloproteinases (MMPs).
Paul S. Thomas (66668) +3 more
core +1 more source