Results 81 to 90 of about 390,769 (349)
Advanced Healthcare Materials, EarlyView.Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu +5 more
wiley +1 more source
Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer
Biomolecular Concepts, 2011 Our review covers the recent epigenetic data that are focused on matrix metalloproteinases (MMPs), their inhibitors (tissue inhibitors of MMPs; TIMPs) and collagen substrates.
Chernov Andrei V., Strongin Alex Y.
doaj +1 more source
4 open, 2019 It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine
Advanced Healthcare Materials, EarlyView.Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi +2 more
wiley +1 more source
MMP-9 expression varies according to molecular subtypes of breast cancer
BMC Cancer, 2014 In 2014, breast cancer remains a major cause of mortality worldwide mostly due to tumor relapse and metastasis. There is currently a great interest in identifying cancer biomarkers and signalling pathways mechanistically related to breast cancer ...
E. Yousef +3 more
semanticscholar +1 more source
Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3 [PDF]
European Journal of Nuclear Medicine and Molecular Imaging, 2010 Purpose: Matrix metalloproteinases (MMPs), a group of more than 20 zinc-containing endopeptidases, are upregulated in many diseases, but several attempts to use radiolabelled MMP inhibitors for imaging tumours have proved unsuccessful in mouse models, possibly due to the limited specificity of these agents or their unfavourable pharmacokinetic profiles.
Pfaffen, Stefanie +4 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena +13 more
wiley +1 more source
Matrix metalloproteinases and their inhibitors
Фармакокинетика и Фармакодинамика, 2019 Metalloproteinase was discovered by Gross and Lapierre in 1962 for the first time. Since then, more than 20 enzymes of this family have been characterized, and their functions have been studied in detail.
O. S. Grigorkevich +2 more
doaj +1 more source
ROC curve of active MMP-2/Pro-MMP-2 ratio.
, 2019 The AUC (A) analyzing active MMP-2/Pro-MMP-2 ratio with a cutoff value of 0.11 illustrates perfect discrimination (AUC = 1) of aneurysmatic from control tissue.
Fabian A. Kari (3324648) +8 more
core +1 more source
Advanced Materials, EarlyView.A microfluidic method is presented which enables parallelized fabrication of rod‐shaped microgels, based on step‐emulsification (SE) droplet generation and subsequent droplet distribution and confinement, combined in a single device. Microgel rods are fabricated in parallel at different flow rates based on two light‐mediated crosslinking chemistries ...
Matthias Mork +5 more
wiley +1 more source