Results 131 to 140 of about 246,934 (340)

Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances [PDF]

, 2011
Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression.
D. Raffo, M. Simian, Raffo, Diego Alejandro, Pontiggia, Osvaldo Alejandro, O. Pontiggia, Simian, Marina   +5 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Physical contact with male influences uterovaginal junction and sperm storage tubule development in Japanese quail (Coturnix japonica) at the onset of the laying cycle

Italian Journal of Animal Science
The sperm storage tubules (SSTs) in the uterovaginal junction (UVJ) of female birds enable long-term sperm storage and are essential for fertility. This study examined how a two-week exposure to a fertile male affects SST morphometry, the incidence of ...
Marta H. Machura, Martina Lichovnikova, Vladimír Zmrhal   +2 more
doaj   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

The role of metalloproteinases (MMPs) in tumor development [PDF]

, 2020
State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua ...
Spoială, Augustina
core   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

MMPs’ Impact on Carcinogenesis in Specific Organs and Systems

Cancer remains a primary global health and economic challenge, characterized by complex mechanisms of carcinogenesis and metastasis. Central to these processes is the dysregulation of matrix metalloproteinases, a family of zinc-dependent proteases. While
Marta Lewoc-Magnuszewska, Barbara Choromańska, Mateusz Maciejczyk, Jacek Dadan, Piotr Myśliwiec   +4 more
core   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

The role of matrix metalloproteinases (MMPs) in human caries

, 2006
The objective of this review is to summarize our understanding of the role of host matrix metalloproteinases (MMPs) in the caries process and to discuss new therapeutic avenues.
Menashi, S., Chaussain-Miller, C., Goldberg, M., Fioretti, F.   +3 more
core   +1 more source

Ratio of pro and active MMPs (-2 and -9).

, 2015
Ratio of pro and active MMPs (-2 and -9).
Yasir Akhtar Khan (740856), Sadiq Umar (740857), Syed M. A. Abidi (740858)   +2 more
core   +1 more source