Results 1 to 10 of about 16,067 (252)

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity

Platelets, 2023
Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets.
Sarah Marie Hicks, Elizabeth Gardiner, Robert Keith Andrews   +2 more
exaly   +3 more sources

Beneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined.
Ritu Kulshrestha, Apoorva Pandey, Amteshwar Jaggi, Surendra Bansal   +3 more
doaj   +1 more source

Bioactive ingredients in activated platelet-rich plasma derived from cord blood and adult blood via Luminex technology: a comparative study

Zhongguo shuxue zazhi, 2023
Objective To compare the bioactive ingredients in activated platelet-rich plasma (PRP) from cord blood and adult blood, explore its reasonable indicators reflecting the inflammatory regulation ability, in order to guide the preparation.
Bingzheng MA, Erhai ZHAO, Jin WANG, Guijie MAO, Jiamei ZHAO, Rong XU, Yuan FANG, Zhenbo ZUO   +7 more
doaj   +1 more source

The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients

Journal of Investigative Surgery, 2022
Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy.
Kayhan Ozdemir, Ismail Zengin, Gamze Guney Eskiler, Havva Belma Kocer, Asuman Deveci Ozkan, Tayfur Demiray, Elif Ozozen Sahin   +6 more
doaj   +1 more source

The Repertoire of Tissue Inhibitors of Metalloproteases: Evolution, Regulation of Extracellular Matrix Proteolysis, Engineering and Therapeutic Challenges

Life, 2022
Tissue inhibitors of metalloproteases (TIMPs) belong to a fascinating protein family expressed in all Metazoa. They act as regulators of the turnover of the extracellular matrix, and they are consistently involved in essential processes.
Salvatore Costa, Maria Antonietta Ragusa, Gabriele Lo Buglio, Simone Dario Scilabra, Aldo Nicosia   +4 more
doaj   +1 more source

Matrix metalloproteinases and their inhibitors in pediatric severe acute pancreatitis

PLoS ONE, 2022
Background Acute pancreatitis (AP) is increasing in incidence in adult and pediatric patients. Identification of patients at high risk for progression to severe acute pancreatitis (SAP) is crucial, as it can lead to increased mortality and health system ...
David S. Vitale, Patrick Lahni, Lindsey Hornung, Tyler Thompson, Peter R. Farrell, Tom K. Lin, Jaimie D. Nathan, Hector R. Wong, Maisam Abu-El-Haija   +8 more
doaj   +2 more sources

Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms [PDF]

Royal Society Open Science, 2015
Tissue inhibitors of metalloproteinases (TIMPs) help regulate the extracellular matrix (ECM) in animals, mostly by inhibiting matrix metalloproteinases (MMPs). They are important activators of mutable collagenous tissue (MCT), which have been extensively
Ronald M. Clouse, Gregorio V. Linchangco, Alexander M. Kerr, Robert W. Reid, Daniel A. Janies   +4 more
doaj   +1 more source

Helminth Coinfection Is Associated With Enhanced Plasma Levels of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Tuberculous Lymphadenitis

Frontiers in Cellular and Infection Microbiology, 2021
Matrix metalloproteinases (MMPs) are crucial for tissue remodeling and repair and are expressed in diverse infections, whereas tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of MMPs.
Gokul Raj Kathamuthu, Gokul Raj Kathamuthu, Kadar Moideen, Kannan Thiruvengadam, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu, Subash Babu   +7 more
doaj   +1 more source

The Association of Matrix Metalloproteinases with Chronic Kidney Disease and Peripheral Vascular Disease: A Light at the End of the Tunnel?

Biomolecules, 2020
Chronic Kidney Disease (CKD) represents a risk factor for fatal and nonfatal cardiovascular (CV) events, including peripheral vascular disease (PVD).
Michele Provenzano, Michele Andreucci, Carlo Garofalo, Teresa Faga, Ashour Michael, Nicola Ielapi, Raffaele Grande, Paolo Sapienza, Stefano de Franciscis, Pasquale Mastroroberto, Raffaele Serra   +10 more
doaj   +1 more source

Comparison of pencil beam and Monte Carlo calculations with ion chamber array measurements for patient-specific quality assurance

Radiation Medicine and Protection, 2022
Objective: To determine under what conditions and criteria comparisons between calculations made with the current clinical treatment planning system (Syngo) and an in-house built TPS (TIMPS) would allow skipping of in-beam portal-specific measurements ...
Yu Deng, Zhi Chen, Qianxia Wang, Pablo Yepes, Zhuangming Shen, Hongliang Chen, Jie Li, Michael F. Moyers   +7 more
doaj   +1 more source