Results 1 to 10 of about 30,124 (283)

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity

Platelets, 2023
Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets.
Christine S-M Lee, Amandeep Kaur, Samantha J Montague   +2 more
exaly   +3 more sources

Expression of TIMPs and MMPs in Ovarian Tumors, Ascites, Ascites-Derived Cells, and Cancer Cell Lines: Characteristic Modulatory Response Before and After Chemotherapy Treatment

Frontiers in Oncology, 2022
BackgroundThe tissue inhibitors of metalloproteinase (TIMPs) and their associated metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential for cancer progression. This study analyzed the expression of TIMP-1,-2,-3 and the
Ruth M Escalona, Nuzhat Ahmed
exaly   +3 more sources

Matrix Metalloproteases in Arterial Hypertension and their Trend after Antihypertensive Treatment [PDF]

Kidney & Blood Pressure Research, 2017
Background/Aims: Arterial hypertension is characterized by vascular remodelling, atherosclerosis and cardiovascular complications. Matrix metalloproteases (MPPs) are endopeptidases produced by all the cells present in the vascular wall and are involved ...
Eugenia Hopps, Rosalia Lo Presti, Gregorio Caimi   +2 more
doaj   +4 more sources

Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence [PDF]

Italian Journal of Pediatrics
Background The mechanism of coronary artery lesions (CALs) persistence in Kawasaki disease (KD) remains unclear. The study aimed to investigate the serum dynamic changes of matrix metalloproteinases (MPPs) and tissue inhibitors (TIMPs) in children with ...
Yaqi Li, Yao Lin, Chen Shen, Jing Zhang, Hui Wang, Qin Zhang, Lin Shi   +6 more
doaj   +2 more sources

Beneficial effects of N-acetylcysteine on protease-antiprotease balance in attenuating bleomycin-induced pulmonary fibrosis in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): The role of N-acetylcysteine (NAC) as an anti-oxidant in attenuating bleomycin-induced pulmonary fibrosis has been reported. However, its effect on parenchymal remodeling via regulating the protease-antiprotease balance is not fully defined.
Ritu Kulshrestha, Apoorva Pandey, Amteshwar Jaggi, Surendra Bansal   +3 more
doaj   +1 more source

Bioactive ingredients in activated platelet-rich plasma derived from cord blood and adult blood via Luminex technology: a comparative study

Zhongguo shuxue zazhi, 2023
Objective To compare the bioactive ingredients in activated platelet-rich plasma (PRP) from cord blood and adult blood, explore its reasonable indicators reflecting the inflammatory regulation ability, in order to guide the preparation.
Bingzheng MA, Erhai ZHAO, Jin WANG, Guijie MAO, Jiamei ZHAO, Rong XU, Yuan FANG, Zhenbo ZUO   +7 more
doaj   +1 more source

The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients

Journal of Investigative Surgery, 2022
Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy.
Kayhan Ozdemir, Ismail Zengin, Gamze Guney Eskiler, Havva Belma Kocer, Asuman Deveci Ozkan, Tayfur Demiray, Elif Ozozen Sahin   +6 more
doaj   +1 more source

The Repertoire of Tissue Inhibitors of Metalloproteases: Evolution, Regulation of Extracellular Matrix Proteolysis, Engineering and Therapeutic Challenges

Life, 2022
Tissue inhibitors of metalloproteases (TIMPs) belong to a fascinating protein family expressed in all Metazoa. They act as regulators of the turnover of the extracellular matrix, and they are consistently involved in essential processes.
Salvatore Costa, Maria Antonietta Ragusa, Gabriele Lo Buglio, Simone Dario Scilabra, Aldo Nicosia   +4 more
doaj   +1 more source

Matrix metalloproteinases and their inhibitors in pediatric severe acute pancreatitis

PLoS ONE, 2022
Background Acute pancreatitis (AP) is increasing in incidence in adult and pediatric patients. Identification of patients at high risk for progression to severe acute pancreatitis (SAP) is crucial, as it can lead to increased mortality and health system ...
David S. Vitale, Patrick Lahni, Lindsey Hornung, Tyler Thompson, Peter R. Farrell, Tom K. Lin, Jaimie D. Nathan, Hector R. Wong, Maisam Abu-El-Haija   +8 more
doaj   +2 more sources

Phylotranscriptomic analysis uncovers a wealth of tissue inhibitor of metalloproteinases variants in echinoderms [PDF]

Royal Society Open Science, 2015
Tissue inhibitors of metalloproteinases (TIMPs) help regulate the extracellular matrix (ECM) in animals, mostly by inhibiting matrix metalloproteinases (MMPs). They are important activators of mutable collagenous tissue (MCT), which have been extensively
Ronald M. Clouse, Gregorio V. Linchangco, Alexander M. Kerr, Robert W. Reid, Daniel A. Janies   +4 more
doaj   +1 more source